| 陈宁,丁琪,袁志华.阿托伐他汀对老年缺血性脑卒中患者氧化低密度脂蛋白和超氧化物歧化酶的影响[J].中国临床保健杂志,2013,1(1):23-25. |
| 阿托伐他汀对老年缺血性脑卒中患者氧化低密度脂蛋白和超氧化物歧化酶的影响 |
| The effect of atorvastatin on the plasma ox-LDL levels and SOD activities in senile patients with ischemic stroke |
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| 中文关键词: 脑血管意外 脂蛋白类,LDL 超氧化物歧化酶 降血脂药 老年人 |
| 英文关键词: Cerebrovascular accident Lipoproteins LDL Superoxide dismutase Insulin resistance Aged |
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| 中文摘要: |
| 目的分析阿托伐他汀在治疗老年急性缺血性脑卒中的抗氧化应激作用。方法将62例急性脑梗死患者随机分为对照组(30例)和研究组(32例),对照组给予常规药物治疗;研究组在常规药物治疗的基础上加用阿托伐他汀治疗。用ELISA法检测患者氧化低密度脂蛋白(ox-LDL)水平和超氧化物歧化酶(SOD)浓度,比较两组患者治疗前后ox-LDL和SOD水平的变化情况。结果治疗10～14 d后研究组ox-LDL和SOD水平较入院时无明显变化,而对照组ox-LDL的水平较入院时升高[(48.46±9.47)×10-5mmol/L比(55.54±8.55)×10-5mmol/L,P<0.01],SOD水平较入院时降低[(20.52±6.66)u/ml比(17.99±5.89)u/ml,P<0.01]。两组治疗后ox-LDL、T-SOD比较,均P<0.05。结论阿托伐他汀从抗氧化应激的角度,可能对急性脑梗死的治疗及预后起重要作用。 |
| 英文摘要: |
| Objective To observe the effect of atorvastatin on oxidative stress and Lipid peroxidation in senile patients with ischemic stroke.Methods 62 patients were divided in control group（n=30） and experimental group（n=32）.Patients in control group were given routine treatment,while patients in experimental group were given atorvastatin besides routine treatment.Plasma levels of ox-LDL and SOD were measured by ELISA method,ox-LDL and SOD were measured in two groups before and after treatment.Results After 10~14 days therapy,serum ox-LDL and SOD in experimental group were not change more.But ox-LDL levels in the control group was higher than that of admission（P0.01） and SOD level was lower than that of admission（P0.01）.Conclusion Atorvastatin may play an important role in the treatment and improment of prognosis of acute cerebral infarction from antioxidant. |
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