| 笪义生,黄河,王剑.瑞舒伐他汀钙对2型糖尿病患者动脉粥样硬化的影响[J].中国临床保健杂志,2013,1(1):40-42. |
| 瑞舒伐他汀钙对2型糖尿病患者动脉粥样硬化的影响 |
| The effect of rosuvastatin calcium on atherosclerosis and its risk factors in type 2 diabetic patients |
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| DOI： |
| 中文关键词: 糖尿病,2型 动脉粥样硬化 降血脂药 |
| 英文关键词: Diabetes mellitus type 2 Atherosclerosis Insulin resistance |
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| 中文摘要: |
| 目的探讨瑞舒伐他汀钙对2型糖尿病(T2DM)患者颈动脉内膜中层厚度(C-IMT)及斑块、血清高敏C-反应蛋白(hs-CRP)、脂联素水平的影响。方法 76例T2DM患者分为观察组和对照组,各38例。所有入选患者均口服降糖药物治疗。观察组在上述治疗基础上口服瑞舒伐他汀钙,观察24周。观察两组患者治疗前后C-IMT和斑块积分,血清hs-CRP和血清脂联素水平。结果两组治疗后C-IMT及斑块积分均较治疗前显著降低(P<0.05);观察组降低的更加明显(P<0.05);2组治疗后hs-CRP水平较治疗前显著降低(P<0.05),脂联素水平较治疗前显著增加(P<0.05);与对照组治疗后比较,观察组降低/增加的更加明显(P<0.05)。结论瑞舒伐他汀钙可明显减轻T2DM患者的动脉粥样硬化程度,其除调脂外还可能与降低hs-CRP水平、升高血清脂联素水平部分有关有关。 |
| 英文摘要: |
| Objective To observe the effect of rosuvastatin calcium on the levels of C-IMT and plaque,serum hs-CRP,adiponectin in patients of type 2 diabetes with atherosclerosis.Methods 76 patients with T2DM were divided into observe groups and the control group.All patients were treated with oral hypoglycemic medication.Observe group was given rosuvastatin calcium on the basis of oral hypoglycemic medication.C-IMT and plaque score,serum of hs-CRP,serum adiponectin levels in the two groups were compared before and after the treatment.Results After the treatment,the C-IMT and plaque score were significantly lower（P0.05） compared with treatment;serum hs-CRP and adiponectin levels were significantly lower than those before treatment（P0.05）;C-IMT,plaque score,serum hs-CRP and adiponectin in observe group were markedly lower than those in control group（P0.05）.Conclusion Rosuvastatin calcium can significantly improve atherosclerosis in patients with T2DM,which may be associated to its effects in reducing hs-CRP levels,increased serum adiponectin levels beyond its lipid-lowering role |
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