| 杨昊,李艳,张莉,徐永霞,吕其阔,朱德发.血清总胆红素与2型糖尿病肾病的相关性研究[J].中国临床保健杂志,2016,(3):246-248. |
| 血清总胆红素与2型糖尿病肾病的相关性研究 |
| Study on relationship between serum total bilirubin and diabetic nephropathy in patients with type 2 diabetes |
| 投稿时间：2015-12-22 |
| DOI：10.3969/J.issn.1672-6790.2016.03.007 |
| 中文关键词: 糖尿病肾病 胆红素 白蛋白尿 危险因素 |
| 英文关键词: Diabetic nephropathies Bilirubin Albuminuria Risk Factors 〖FL |
| 基金项目:国家自然科学基金(81272152) |
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| 中文摘要: |
| 目的 探寻血清总胆红素(TB)与2型糖尿病肾病的相关性。方法 将126例住院2型糖尿病患者按尿白蛋白排泄率(UAER)将其分为正常蛋白尿组、早期糖尿病肾病组、临床糖尿病肾病组,比较三组血清TB水平及其他临床生化资料,探寻血清TB与UAER的相关性,并采用多因素Logistic回归分析探讨糖尿病肾病发病的影响因素。结果 三组间年龄、体质量指数(BMI)、舒张压(DBP)、尿酸(UA)、总胆固醇(TCH)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)比较差异均无统计学意义(P＞0.05),糖尿病病程、收缩压(SBP)、TB在不同组间差异有统计学意义(P＜0.05)。Spearman相关分析显示血清TB与UAER显著负相关(r=-0.32,P＜0.01)。Logistic多元回归分析显示BMI和TB是糖尿病肾病的独立影响因素(OR=1.189、0.850；P＜0.05、P＜0.01)。结论 血清TB与2型糖尿病肾病呈负相关,其可能成为糖尿病肾病的一种新治疗靶点。 |
| 英文摘要: |
| Objective To explore the relationship between serum total bilirubin(TB) and diabetic nephropathy in patients with type 2 diabetes. Methods A total of 126 hospitalized patients with type 2 diabetes were including and divided into three groups according to urinary albumin excretion rate(UAER):normal albuminuria group, early phase diabetic nephropathy group, and clinical diabetic nephropathy group. The serum TB and other clinical and biochemical assessment data were recorded and compared between three groups. The relationship between serum TB and UAER was analyzed. The risk factors of diabetic nephropathy was evaluated by multiple logistic regression analysis. Results There was no significant difference in the age, BMI, DBP, UA, TCH, TG, LDL-C, HbA1c among three groups(P＞0.05). There were significant difference among the groups in the diabetic duration, SBP and TB (P＜0.05). The analysis of spearman showed that the level of serum TB was negatively associated with UAER(r=-0.32,P＜0.01). Logistic regression analysis showed that BMI and TB were independent influence factors of diabetic nephropathy(OR=1.189,0.850；P＜0.05,P＜0.01,respectively). Conclusion The serum TB may be a protective factor for diabetic nephropathy in type 2 diabetic patients,which might be a potential therapeutic target for diabetic nephropathy. |
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