| 邹婷,朱梅生,周晓辉,苗海军,张雷.新疆维吾尔族、汉族老年人轻度认知功能障碍与血浆同型半胱氨酸水平的相关性[J].中国临床保健杂志,2016,(4):343-345. |
| 新疆维吾尔族、汉族老年人轻度认知功能障碍与血浆同型半胱氨酸水平的相关性 |
| Correlation study between mild cognitive impairment and homocysteine of Uygurs and Hans aged in Xinjiang |
| 投稿时间：2015-08-10 |
| DOI：10.3969/J.issn.1672-6790.2016.04.002 |
| 中文关键词: 轻度认知障碍 半胱氨酸 维吾尔族 汉族 危险因素 |
| 英文关键词: Mild cognitive impairment Cysteine Uygur nationality Han nationality Risk factors 〖FL |
| 基金项目:国家自然科学基金资助项目(30960402) |
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| 中文摘要: |
| 目的 探讨新疆维吾尔族、汉族老年人轻度认知功能障碍(MCI)与血浆同型半胱氨酸(Hcy)水平之间的关联。方法 采用分层随机多级整群抽样方式,根据美国精神病学会的精神障碍诊断和统计手册第4版修订版(DSM–IV)中MCI的临床诊断标准,随机抽取新疆南疆、东疆、北疆等区域,年龄大于等于60岁的维、汉两民族老年人5398例进行MCI的流行病学调查。在此基础上采用病例-对照研究方法,从已诊断为MCI的患者中选取资料完整的314例作为MCI组(维吾尔族161例,汉族153例),同时选取对照组299例(维吾尔族149例,汉族150例),应用酶联免疫法检测两组血浆Hcy浓度,比较之间的差异。结果 整群MCI组血浆Hcy水平[(17.11±9.17)μmol/L]高于对照组[(12.65±4.57)μmol/L](P＜0.05)；其中维吾尔族MCI组[(17.23±8.31)μmol/L]、汉族MCI组[(16.99±10.28)μmol/L]血浆Hcy水平均分别高于其对照组(P＜0.01)；在不同年龄段中,整群MCI组血浆Hcy水平60~69岁:(16.99±8.62)μmol/L；70~79岁:(19.73±10.5)μmol/L；≥80岁:(20.97±6.03)μmol/L,均高于对照组(P＜0.05),且随着年龄的增长,血浆Hcy水平逐渐增高(P＜0.05)；男性MCI组[(15.34±8.64)μmol/L]及女性MCI组[(14.58±6.58)μmol/L]血浆Hcy水平均高于对照组(P＜0.05)。结论 血浆Hcy水平与新疆老年人MCI的发病相关,且其随着年龄增长而升高,高Hcy血症是新疆老年人MCI发病的危险因素之一。 |
| 英文摘要: |
| Objective To explore the association between mild cognitive impairment and plasma homocysteine of Uygurs and hans aged in Xinjiang.Methods A total of 5398 Uygurs and Hans aged 60 years or older were surveyed in south,east and north of Xinjiang by divided-levels,random,cluster sampling approaches a ccording to the DSM-IV(Diagnostic and Statistical Manual of Mental Disorders,forth version).Based on the epidemiological investigation,the case-control anlaysis had been adopted.We selected 314 patients with MCI as MCI group (161 Uygurs,153 Hans) and 299 normal elderly people as control group (149 Uighurs,150 Hans); plasma homocysteine of two groups were compared.Results Plasma homocysteine of MCI group was significant higher than that in the control group (P＜0.05),and the result was same in Uygurs and Hans respectively(P＜0.01).Plasma homocysteine of MCI group was higher than the control group in different ages (P＜0.05),and the homocysteine was gradually increased with age (P＜0.05).Plasma homocysteine of male and female in MCI group was higher than that in control group (P＜0.05).Conclusion Plasma homocysteine relates with the pathogenesis in aged with MCI in Xinjiang ,and increased with age.High plasma homocysteine is an independent risk factor of aged with MCI in Xinjiang,China. |
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