| 刘晓红,陈健,杜雷,石皖荣,王木杉,杨晨,夏本跃,冷闰杰,陆丽,刘莉.利伐沙班抗凝治疗老年非瓣膜性心房颤动患者的效果[J].中国临床保健杂志,2016,(4):397-399. |
| 利伐沙班抗凝治疗老年非瓣膜性心房颤动患者的效果 |
| The anticoagulant therapy for the elderly patients with nonvalvular atrial fibrillation with rivaroxaban |
| 投稿时间：2015-06-29 |
| DOI：10.3969/J.issn.1672-6790.2016.04.021 |
| 中文关键词: 心房颤动 抗凝药 华法林 老年人 |
| 英文关键词: Atrial fibrillation Anticoagulants Warfarin Aged〖FL |
| 基金项目: |
| 作者 | 单位 | E-mail | | 刘晓红 | 新疆克拉玛依市中心医院心血管内科,834000 | lxh51666@sohu.com | | 陈健 | 安徽医科大学第四附属医院,合肥 230002 | chenj2008.happy@163.com | | 杜雷 | 新疆克拉玛依市中心医院心血管内科,834000 | | | 石皖荣 | 安徽医科大学第四附属医院,合肥 230002 | | | 王木杉 | 安徽医科大学第四附属医院,合肥 230002 | | | 杨晨 | 新疆克拉玛依市中心医院心血管内科,834000 | | | 夏本跃 | 安徽医科大学第四附属医院,合肥 230002 | | | 冷闰杰 | 新疆克拉玛依市中心医院心血管内科,834000 | | | 陆丽 | 安徽医科大学第四附属医院,合肥 230002 | | | 刘莉 | 安徽医科大学第四附属医院,合肥 230002 | |
|
| 摘要点击次数: 6715 |
| 全文下载次数: 3772 |
| 中文摘要: |
| 目的 探讨老年非瓣膜性心房颤动患者应用利伐沙班的有效性及安全性。方法 选择46例住院老年非瓣膜性心房颤动患者,采用随机数字表法分为对照组23例及观察组23例,观察组在基础上口服利伐沙班10 mg/d,对照组口服华法林,调整剂量将国际标准化时间调整为1.8～2.5之间,两组随访均为6个月。比较两组栓塞出血不良事件发生情况。结果 对照组卒中发生率5.0％,观察组发生率为3.8％,差异无统计学意义(P＞0.05)；两组均无严重及中度出血,观察组轻度出血发生率为7.6%,对照组轻度出血发生率为5.0%,差异无统计学意义(P＞0.05)。结论 对老年非瓣膜性心房颤动患者采用小剂量利伐沙班治疗效果较好,且较为安全,利伐沙班与华法林抗凝治疗效果相当,可明显减少栓塞事件。 |
| 英文摘要: |
| Objective To investigate the effectiveness and safety of rivaroxaban for the elderly patients with nonvalvular atrial fibrillation.Methods 46 elderly patients with non valvular atrial fibrillationwererandomized were divided into control group (23 cases) and observation group (23 cases),The patients in the observation group were treated with oral rivaroxaban (10mg/d) was on the basic of routine treatment,and in the control group the patients was treated with oral warfarin,which the International standardization ratio were adjusted in the range between 1.8 and 2.5.The follow-up periodwas 6 months.The incidence of adverse events in the two groups of hemorrhage were compared.Results The incidence of stroke was 5.0% and 3.8% in the control group and the observation group,respectively,the difference was not statistically significant (P>0.05); There were no serious and moderate bleeding in the two groups,The incidence of mild bleeding was 7.6% and 5.0% in the observation group and the control group,respectively,the difference was not statistically significant (P>0.05).Conclusions The low-dose rivaroxaban treatment for the elderly patients with non valvular atrial fibrillation is more effective and safety,and the effect of rivaroxaban and warfar for anticoagulant is similar,which could significantly reduce the embolic events. |
|
查看全文
|
| 关闭 |
|
|
|