| 王晓楠,程民,胡世莲.循环肿瘤DNA在胃癌发生发展中的作用[J].中国临床保健杂志,2017,20(1):109-112. |
| 循环肿瘤DNA在胃癌发生发展中的作用 |
| The role of tumor circulating DNA in the development of gastric cancer and research progress |
| 投稿时间：2016-08-17 |
| DOI：10.3969/J.issn.1672-6790.2017.01.035 |
| 中文关键词: 胃肿瘤 肿瘤细胞,循环 基因检测 分子靶向治疗 |
| 英文关键词: Stomach neoplasms Neoplastic cells,circulating Genetic testing Molecular targeted therapy〖FL |
| 基金项目:国家自然科学基金(81071808)；安徽省自然科学基金面上项目(1408085MH167)；安徽省国际科技合作项目(1303063017) |
| 作者 | 单位 | E-mail | | 王晓楠 | 安徽医科大学附属安徽省立医院、安徽省立医院,安徽省老年医学研究所,肿瘤免疫与营养治疗安徽省重点实验室,安徽省循证医学中心,合肥 230001 | 1006445947@qq.com | | 程民 | 安徽医科大学附属安徽省立医院、安徽省立医院,安徽省老年医学研究所,肿瘤免疫与营养治疗安徽省重点实验室,安徽省循证医学中心,合肥 230001 | | | 胡世莲 | 安徽医科大学附属安徽省立医院、安徽省立医院,安徽省老年医学研究所,肿瘤免疫与营养治疗安徽省重点实验室,安徽省循证医学中心,合肥 230001 | hushilian@126.com |
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| 中文摘要: |
| 近年来,胃癌的发病率和死亡率居高不下,早期发现、早期诊断、早期治疗是防治胃癌的关键。随着现代医学发展,肿瘤标志物已应用于临床诊断,但由于肿瘤标志物灵敏度和特异度较低,临床应用局限,难以满足"精准医疗"要求。研究表明,循环肿瘤DNA(ctDNA)检测技术是一种快速、高效、相对无创性的新型"液体活检"技术,能够实时监测机体肿瘤状态、转移、复发及预后评估。本文阐述ctDNA与胃癌的关系,介绍目前常用的ctDNA检测技术,探讨ctDNA在胃癌临床诊疗中的应用价值。 |
| 英文摘要: |
| With increasing morbidity and mortality of gastric cancer in recent years, the early detection, diagnosis and treatment are critical to the prophylaxis and therapy of gastric cancer nowadays. Tumor markers have gain growing concern to its clinical applications but still confined to the sensitivity and specificity which make it hard to fit for "precision medicine". Some research have shown that circulating tumor DNA(ctDNA) detection is a kind of "liquid biopsy " technology which is rapid、effective and noninvasive. The state of tumor, including metastasis, recurrence and prognosis can be monitored by detecting ctDNA. This review focuses on the relationship between ctDNA and gastric cancer, as well as the detection technology commonly used to explore the application of ctDNA in clinical diagnosis and treatment of gastric cancer. |
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