李志军,邹为,唐娜,杨渊.利舒康胶囊治疗非痴呆性血管性认知功能障碍的效果[J].中国临床保健杂志,2017,20(2):158-161. |
利舒康胶囊治疗非痴呆性血管性认知功能障碍的效果 |
Effects of capsule LI SHU KANG on the patients with not dementia vascular cognitive impairment |
投稿时间:2016-08-26 |
DOI:10.3969/J.issn.1672-6790.2017.02.013 |
中文关键词: 脑血管障碍 认知障碍 超氧化物歧化酶 中成药 |
英文关键词: Cerebrovascular disorders Cognition disorders Superoxide dismutase Chinese patent drugs〖FL |
基金项目:教育部留学回国人员科研启动基金(教外司留[2014]1685号);华中科技大学院系自主创新研究基金资助(2016YXMS109) |
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中文摘要: |
目的 观察利舒康胶囊治疗非痴呆性血管性认知功能障碍(VCIND)的临床疗效。方法 通过简易智能精神状态量表(MMSE)和蒙特利尔认知评估量表(MoCA)选取126例VCIND患者为观察对象,随机数字表法平均分为利舒康组和对照组。比较治疗前后MMSE、MoCA评分总分和认知功能亚项以及血清超氧化物歧化酶(SOD)水平等变化。结果 治疗前,两组VCIND 患者血清SOD值较正常值明显减低(P<0.01),但两组间血清SOD值、MMSE 和MoCA 评分差异无统计学意义(P>0.05) 。治疗后两组血清SOD值、MMSE 及MoCA 评分较治疗前均显著升高(P<0.05) ;与对照组相比,利舒康组改善更为显著(P<0.05)。对MoCA各认知功能亚项评分分析显示:与对照组相比,利舒康胶囊治疗组在提高VCIND患者视空间与执行力、注意力、延迟回忆以及抽象能力方面评分更明显 (P<0.01)。结论 利舒康胶囊具有抗氧化作用,能够改善VCIND患者认知功能。 |
英文摘要: |
Objective To observe the effects of capsule LI SHU KANG on the patients with not dementia vascular cognitive impairment (VCIND).Methods One hundred and twenty-six patients of VCIND were randomly divided into control group and capsule LI SHU KANG group.The recognition of each group was assessed by the mini-mental state examination scale (MMSE) and Montreal cognitive assessment scale (MoCA) on the first day and 3 months later,as well as the super oxide dismutase (SOD) were measured in each group.Results The SOD were obviously decreased in both groups compared to normal control(P<0.01).However,there were no significant differences between two groups before treatment in SOD,MMSE and MoCA scale (P>0.05).Serum SOD,MMSE and MoCA scale after treatment in both groups were significantly higher than those before treatment(P<0.05).Compared with the control group,the improvment of SOD,MMSE and MoCA scale of patients in capsule LI SHU KANG group were more obvious(P<0.05).The sub-domains of MoCA scale in the aspects of visuospatial abilities,executive functions,attention,short-term memory recall task and abstract were more obvious(P<0.01).Conclusions The capsule LI SHU KANG is effective to improve the recognition impairment of VCIND by antioxidant. |
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