| 马其辉,黄菁菁,陈日,王家乙,罗蓉.右美托咪定联合氟哌啶醇与单用氟哌啶醇治疗老年谵妄的疗效比较[J].中国临床保健杂志,2017,20(4):370-372. |
| 右美托咪定联合氟哌啶醇与单用氟哌啶醇治疗老年谵妄的疗效比较 |
| The efficacy comparison between dexmedetomidine combined with haloperidol and haloperidol in treating elderly delirium |
| 投稿时间：2016-11-10 |
| DOI：10.3969/J.issn.1672-6790.2017.04.010 |
| 中文关键词: 谵妄 氟哌啶醇 肾上腺素能α激动剂 老年人 |
| 英文关键词: Delirium Haloperidol Adrenergic alpha-agonists Aged〖FL |
| 基金项目:浙江省医药卫生一般研究计划(2015KYB-196) |
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| 中文摘要: |
| 目的 分析右美托咪定联合氟哌啶醇与单用氟哌啶醇治疗老年谵妄效果。方法 随机数字表法将184例老年谵妄患者分为两组,每组92例。对照组给予氟哌啶醇,观察组在此基础上加用右美托咪定。治疗后,比较两组各时间点谵妄评定方法中文修订版(CAM-CR)、临床总体印象量表病情严重程度(CGI-SI)、谵妄评定量表-98修订版(DRS-R-98)的评分,并统计两组不良反应。结果 治疗1 d、2 d、3 d时,两组CAM-CR、CGI-SI、DRS-R-98评分显著降低(P<0.05),且观察组CAM-CR、CGI-SI、DRS-R-98评分显著低于对照组(P<0.05)。观察组不良反应率为6.5%,显著低于对照组的20.7%(P<0.05)。结论 相比于单用氟哌啶醇,右美托咪定联合氟哌啶醇治疗老年谵妄效果更好,且不良反应较少。 |
| 英文摘要: |
| Objective To compare the efficacy of dexmedetomidine combined with haloperidol and only haloperidol on treatment of elderly delirium.Methods 184 elderly delirium patients were randomly divided into two groups,namely control group and observation group.Patients in control group were given haloperidol,and patients in observation group were added dexmedetomidine.After treatment,the CAM-CR,CGI-SI,DRS-R-98 of two groups at each time point were compared,and the adverse reactions of two groups were accounted.Results After treatment 1d,2d and 3d,the CAM-CR,CGI-SI and DRS-R-98 scores of two groups were significantly reduced (P<0.05) and the CAM-CR,CGI-SI and DRS-R-98 scores of observation group were significantly lower than those of control group (P<0.05).The adverse reaction rate of observation group was 6.5%,which was significantly lower than that of control group (P<0.05).Conclusion Compared with haloperidol alone,dexmedetomidine combined with haloperidol could treat elderly delirium more effectively with fewer adverse reactions. |
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