| 陈静,顾朋颖,丁琪,袁志华,靳松,靳珊珊,方艺,李楠,唐杨琛,刘林青.老年缺血性卒中患者血胆红素水平与颈动脉粥样硬化的相关性[J].中国临床保健杂志,2017,20(6):696-699. |
| 老年缺血性卒中患者血胆红素水平与颈动脉粥样硬化的相关性 |
| Correlation study between serum bilirubin and carotid atherosclerosis in elderly patients with acute ischemic stroke |
| 投稿时间：2017-02-21 |
| DOI：10.3969/J.issn.1672-6790.2017.06.020 |
| 中文关键词: 卒中 动脉粥样硬化 胆红素 危险因素 |
| 英文关键词: Stroke Atherosclerosis Bilirubin Risk factors〖FL |
| 基金项目:安徽省卫生厅医学科研计划(13zc010) |
| 作者 | 单位 | E-mail | | 陈静 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | ishida-akila@163.com | | 顾朋颖 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | hellengpy@163.com | | 丁琪 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | | | 袁志华 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | | | 靳松 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | | | 靳珊珊 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | | | 方艺 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | | | 李楠 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | | | 唐杨琛 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | | | 刘林青 | 安徽医科大学附属省立医院南区老年医学科,合肥 230001 | |
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| 中文摘要: |
| 目的 探讨急性缺血性卒中患者颈动脉粥样硬化与血清胆红素水平的关系。方法 测定95例老年急性缺血性卒中患者的血清总胆红素(TBIL)、直接胆红素(DBIL)和间接胆红素(IBIL)胆红素水平,同时行颈部彩色多普勒血管超声检测,根据颈动脉内膜中层厚度(IMT)及形态分为无斑块组、动脉硬化组以及斑块形成组,观察三组间血清胆红素是否有差异。结果 动脉硬化组的TBIL、DBIL和IBIL水平分别为(10.26±3.79)mmol/L、(2.76±1.97)mmol/L和(7.90±3.39)mmol/L,斑块形成组的TBIL、DBIL和IBIL水平分别为(10.87±2.55)mmol/L、(2.35±1.13)mmol/L和(8.53±1.99)mmol/L,无斑块组的TBIL、DBIL和IBIL水平分别为(13.69±4.62)mmol/L、(2.67±1.01)mmol/L和(11.03±4.05)mmol/L,动脉硬化组、斑块形成组的TBIL和IBIL水平均低于无斑块组(P＜0.05),而动脉硬化组与斑块形成组间TIBL、IBIL及DBIL水平均差异无统计学意义(P＞0.05)。Pearson相关分析示,颈动脉IMT值与TBIL(r=-0.272,P=0.008)和IBIL(r=-0.277,P=0.007)水平存在负相关。结论 低水平胆红素可能是颈动脉粥样硬化的高危因素,增加缺血性卒中的发生风险,但颈动脉粥样硬化病变严重程度可能与胆红素的降低水平无关。 |
| 英文摘要: |
| Objective To explore the correlation between serum bilirubin and carotid atherosclerosis in patients with acute ischemic stroke.Method Carotid artery ultrasonography was performed in 95 patients with acute ischemic stoke.Total bilirubin,direct bilirubin and indirect bilirubin were detected at the same time.All objects were divided into no plaque group,atherosclerosis group and plaque formation group according to the intima-media thickness(IMT).The differences of bilirubin among three groups was observed.Result The serum TBIL,DBILand IBIL of atherosclerosis group were(10.26±3.79)mmol/L,(2.76±1.97)mmol/L and(7.90±3.39)mmol/L respectively,and those in plaque formation group were(10.87±2.55)mmol/L,(2.35±1.13)mmol/L and(8.53±1.99)mmol/L.While the levels in no plaque group were(13.69±4.62)mmol/L,(2.67±1.01)mmol/L and(11.03±4.05)mmol/L.The TBIL and IBIL of atherosclerosis and plaque formation group were lower than the no plaque group respectively (P<0.05),the differences of TBIL,DBILand IBIL between atherosclerotic group and the plaque formation group had no statistical significance (P>0.05).Correlation analysis showed that the carotid intima-media thickness(IMT) was negatively correlated with the TBIL (r=-0.272,P=0.008)and IBIL(r=-0.277,P=0.007).Conclusion Low serum bilirubin probablely increase the risk of ischemic stroke. |
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