| 陈莉,戴朦,李红旗,章琦,尹长森,胡立群.老年高血压患者超敏C反应蛋白和糖化血红蛋白水平与颈动脉粥样硬化之间的关系[J].中国临床保健杂志,2018,21(4):433-436. |
| 老年高血压患者超敏C反应蛋白和糖化血红蛋白水平与颈动脉粥样硬化之间的关系 |
| The relationship between high sensitivity C-reactive protein and glycosylated hemoglobin and carotid atherosclerosis in elderly patients with hypertension |
| 投稿时间：2018-04-02 |
| DOI：10.3969/J.issn.1672-6790.2018.04.001 |
| 中文关键词: 高血压 动脉粥样硬化 C反应蛋白质 血红蛋白A,糖基化 老年人 |
| 英文关键词: Hypertension Atherosclerosis C-reactive protein Hemoglobin A,glycosylated Aged〖FL |
| 基金项目:安徽省公益性联动项目(1604f0804009) |
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| 中文摘要: |
| 目的 探讨老年高血压患者超敏C反应蛋白(hs-CRP)及糖化血红蛋白(HbA1c)水平与颈动脉粥样硬化的关系。方法 采用超声检测159例老年高血压患者的颈动脉内膜中层厚度(IMT),0.8 mm≤IMT＜1.0 mm为内膜正常组；1.0 mm≤IMT＜1.2 mm为内膜增厚组；IMT≥1.2 mm为斑块形成组。比较三组间多项临床资料及生化指标水平,并进一步分析颈动脉斑块特点。通过分析各指标与IMT的相关性,评价颈动脉粥样硬化斑块形成的相关因素。结果 三组间性别、年龄、体质指数(BMI)、高血压病程、血尿酸(UA)、空腹血糖(FPG)、总胆固醇(TC)对比,差异无统计学意义(P>0.05)；三酰甘油(TG)在斑块形成组高于内膜正常组(P<0.05),高密度脂蛋白胆固醇(HDL-C)在内膜增厚组和斑块形成组均低于内膜正常组(P<0.05),低密度脂蛋白胆固醇(LDL-C)、hs-CRP、HbA1c水平三组间差异有统计学意义,斑块组三个指标均最高,内膜正常组最低(P<0.01)；IMT与LDL-C(r=0.57,P<0.01)、hs-CRP(r=0.55,P<0.01)、HbA1c(r=0.53,P<0.01)呈正相关,与HDL-C呈负相关(r=-0.35,P<0.01),与病程、UA、FPG、TC、TG无相关性；hs-CRP、HbA1c、IMT为颈动脉粥样硬化斑块形成的独立危险因素(P＜0.05)；hs-CRP及HbA1c水平不稳定斑块患者明显高于稳定斑块患者(P＜0.05)。结论 老年高血压患者血清hs-CRP、HbA1c水平升高是颈动脉粥样硬化病变发生的危险因素。 |
| 英文摘要: |
| Objective To investigate the relationship between high sensitivity C-reactive protein (hs-CRP) and glycosylated hemoglobin (HbA1c) levels and carotid atherosclerosis in elderly patients with hypertension.Methods159 elderly hypertensive patients underwent carotid ultrasonography,and were divided into three groups according to the carotid intima-media thickness (IMT),normal intima group,intimal thickening group,plaque formation group.Clinical data and biochemical indicators and carotid plaque formation were compared.The correlation between each index and IMT were analyzed,and the risk factors influencing the formation of carotid atherosclerosis plaque were analyzed by Logistic regression.Results There were no significant differences in gender,age,BMI,duration of hypertension,UA,FPG and TC between the three groups (P>0.05).The level of triglyceride(TG) in plaque formation group was significantly higher than that in normal endometrium group (P<0.05),while HDL-C in intimal thickening group and plaque formation group was lower than that in normal endometrium group(P<0.05).There were significant differences among the three groups in the levels of LDL-C,hs-CRP and HbA1c.The three indexes were the highest in plaque group and the lowest in normal endometrium group(P<0.01).There were positive correlation between IMT and HDL-C (r=0.57,P<0.01),hs-CRP(r=0.55,P<0.01),HbA1c (P<0.05).Hs-CRP,HbA1c and IMT were independent risk factors of carotid atherosclerosis plaque formation (P<0.05).The levels of hs-CRP and HbA1c in patients with unstable plaque were significantly higher than those in patients with stable plaque (P<0.05).Conclusion Serum levels of hs-CRP and HbA1c are the risk factors of carotid atherosclerosis in elderly patients with hypertension. |
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