| 陈宏,刘涛,邓诗武,侯霁芯,黄磊,王秋林.卡维地洛治疗射血分数保留心力衰竭的疗效及安全性Meta分析[J].中国临床保健杂志,2018,21(4):471-476. |
| 卡维地洛治疗射血分数保留心力衰竭的疗效及安全性Meta分析 |
| Efficacy and safety of carvedilol for patients with heart failure with preserved ejection fraction:a Meta analysis |
| 投稿时间：2017-06-19 |
| DOI：10.3969/J.issn.1672-6790.2018.04.009 |
| 中文关键词: 心力衰竭 肾上腺素能拮抗剂 Meta分析 |
| 英文关键词: Heart failure Adrenergic antagonists Meta-analysis 〖FL |
| 基金项目:四川省科技厅基金资助项目(2016SZ0052) |
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| 中文摘要: |
| 目的 对卡维地洛治疗射血分数保留心力衰竭(HFpEF)的疗效及安全性进行Meta分析。方法计算机检索PubMed、EMbase、The Cochrane Library、中国生物医学文献数据库、中国万方数据库、中国知网数据库,检索时间从建库截止到2016年12月,纳入卡维地洛治疗HFpEF患者疗效及安全性的随机对照实验,文献语种限定为中文和英文,提取相关资料,对纳入研究的方法学质量进行评价,用RevMan5.3软件进行Meta分析结果 纳入7个研究,共计667例患者。Meta分析结果显示:与对照组相比卡维地洛能改善HFpEF患者的临床心功能疗效(RR=1.29,95%CI:1.05~1.58,P=0.02)和显著改善左室舒张功能(E/A值:MD=0.20,95%CI:0.11~0.29,P<0.001)。结论 卡维地洛能改善HFpEF患者心功能和左室舒张功能。 |
| 英文摘要: |
| Objective To systematically review the efficacy and safety of carvedilol in the treatment of patients with heart failure with preserved ejection fraction (HFpEF) by meta analysis.Methods A thorough literature search about studies on the relationship between carvedilol and Patients with heart failure with preserved ejection fraction was performed among PubMed,Embase,Cochrane Library,CBM,WANFANG,CNKI database form inception to December 2016..Only Chinese and English language papers were included.Then relevant datas were extracted and the quality of studies was evaluated.Meta-analysis was performed by using RevMan 5.3 software.Results Seven randomized controlled trials involving 667 patients were included in the meta analysis.Compared with the control group,carvedilol resulted in a improvement of efficacy(RR=1.29,95%CI:1.05-1.58,P=0.02) and significant improvement of diastolic function in HFpEF patients(E/A ratio:MD=0.20,95%CI:0.11-0.29,P<0.001). Conclusion Carvedilol can improve the heart and diastolic function in patients with HEpEF. |
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