| 代丽娟,宋立群,贠捷,张德欣,于思明,马艳春.虫草素抗肾纤维化研究进展[J].中国临床保健杂志,2019,22(1):115-119. |
| 虫草素抗肾纤维化研究进展 |
| Research progress of cordycepin in anti-renal fibrosis |
| 投稿时间：2018-10-19 |
| DOI：10.3969/J.issn.1672-6790.2019.01.031 |
| 中文关键词: 虫草素 肾纤维化 肾功能衰竭,慢性 信号传导 |
| 英文关键词: Cordycepin Fibrosis,kidney Kidney failure,chronic Signal transduction 〖FL |
| 基金项目:国家中医药管理局国家中医临床科研基地业务建设第二批科研专项课题；黑龙江省科学基金项目(H2016078)；黑龙江省科学基金项目(H2016059) |
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| 中文摘要: |
| 虫草素是从蛹虫草中分离出的一种核苷类抗生素,具有明显的抗肾纤维化作用。通过对肾纤维化病理机制的研究,阐述虫草素可从细胞分子学水平调控多种细胞因子,从而介导七大信号通路,阻碍其信号传导。七种通路相互关联,从而延缓肾纤维化及慢性肾脏病的进展。 |
| 英文摘要: |
| Cordycepin,an nucleoside antibiotic isolated from Cordyceps militaris.Cordycepin has obvious effect of anti-renal fibrosis.The pathological mechanism of renal fibrosis was studied.The researching of Cordycepin describes that they can regulate the expression of various cytokines from cell molecular level.They can mediate signal path,impede signal transmission.The seven pathways are interrelated,they can prevent renal fibrosis,delay the progress of chronic kidney disease. |
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