| 赵倩,耿德勤,程言博,等.入院时血清miR-20b、miR-24、miR-137水平对老年急性缺血性脑卒中患者预后的预测价值[J].中国临床保健杂志,2024,27(3):326-329. |
| 入院时血清miR-20b、miR-24、miR-137水平对老年急性缺血性脑卒中患者预后的预测价值 |
| Predictive value of serum miR-20b,miR-24 and miR-137 levels at admission for the prognosis in elderly patients with acute ischemic stroke |
| 投稿时间：2024-01-08 |
| DOI：10.3969/J.issn.1672-6790.2024.03.009 |
| 中文关键词: 循环微RNA 缺血性卒中 危险因素 预后 老年人 |
| 英文关键词: Circulating microRNA Ischemic stroke Risk Factors Prognosis Aged〖FL |
| 基金项目:国家卫生健康委脑卒中防治工程委员会项目(GN-2018R0009) |
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| 中文摘要: |
| 目的 探讨入院时血清miR-20b、miR-24、miR-137水平对老年急性缺血性脑卒中(AIS)患者预后的预测价值。方法 选取2022年1月至2023年1月在徐州医科大学附属医院神经内科收治入院的138例老年AIS患者。根据改良Rankin量表得分(mRS)分为预后良好组(mRS≤2分,82例)和预后不良组(mRS>2分,56例)。在入院收治时,采用实时荧光定量RT-PCR法检测各组患者血清miR-20b、miR-24、miR-137水平；采用受试者工作特征曲线(ROC)分析血清miR-20b、miR-24、miR-137水平预测老年AIS患者预后不良的价值；通过1∶1倾向性评分匹配(PSM)均衡预后良好组和预后不良组协变量之间的差异,采用多因素logistic回归分析老年AIS患者预后不良的独立危险因素。结果 预后不良组总胆固醇、低密度脂蛋白胆固醇水平高于预后良好组,高密度脂蛋白胆固醇低于预后良好组(P<0.05)；预后不良组的血清miR-20b水平高于预后良好组,miR-24、miR-137水平低于预后良好组(P<0.05)；ROC分析可见,血清miR-20b、miR-24、miR-137及联合检测预测老年AIS预后不良的AUC分别为0.751、0.707、0.732、0.812,灵敏度分别为81.20%、74.40%、76.80%、92.90%；特异度分别为79.30%、73.50%、73.30%、69.50%；多因素分析显示,miR-20b>1.78,miR-24<0.94,miR-137<0.93是导致老年AIS患者预后不良的独立危险因素(P<0.05)。结论 血清miR-20b、miR-24、miR-137三者联合检测对入院后的老年AIS预后不良具有一定的预测价值。 |
| 英文摘要: |
| Objective To explore the predictive value of serum miR-20b,miR-24 and miR-137 levels at admission for the prognosis in elderly patients with acute ischemic stroke (AIS).Methods A total of 138 elderly patients with AIS admitted to Department of Neurology in Affiliated Hospital of Xuzhou Medical University were enrolled between January 2022 and January 2023.According to scores of modified Rankin scale (mRS) at admission,they were divided into good prognosis group (≤2 points,n=82) and poor prognosis group (>2 points,n=56).The levels of serum miR-20b,miR-24 and miR-137 were detected by real-time fluorescence quantitative RT-PCR,and their predictive value for poor prognosis was analyzed by receiver operating characteristic (ROC) curves.The differences in covariates between good prognosis group and poor prognosis group were balanced by 1∶1 propensity score matching (PSM).The independent risk factors of poor prognosis in elderly AIS patients were analyzed by multivariate logistic regression analysis.Results The levels of total cholesterol and low-density lipoprotein in poor prognosis group were higher than those in good prognosis group,while high-density lipoprotein was lower than that in good prognosis group (P<0.05).The level of serum miR-20b in poor prognosis group was higher than that in good prognosis group,while levels of miR-24 and miR-137 were lower than those in good prognosis group (P<0.05).ROC curves analysis showed that AUC,sensitivity and specificity of serum miR-20b,miR-24,miR-137 and combined detection for predicting poor prognosis were (0.751,0.707,0.732,0.812),(81.20%,74.40%,76.80%,92.90%) and (79.30%,73.50%,73.30%,69.50%),respectively.Multivariate analysis showed that miR-20b>1.78,miR-24<0.94 and miR-137<0.93 were independent risk factors of poor prognosis in elderly patients with AIS (P<0.05).Conclusion Combined detection of serum miR-20b,miR-24 and miR-137 has certain predictive value for the prognosis of elderly patients with AIS after admission. |
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