| 沈琪琦,张之龄,童小文,等.依达拉奉治疗急性脑出血的疗效分析[J].中国临床保健杂志,2016,(1):19-21. |
| 依达拉奉治疗急性脑出血的疗效分析 |
| Effects of edaravone for treating acute intracerebral hemorrhage |
| 投稿时间：2015-04-24 |
| DOI：10.3969/J.issn.1672-6790.2016.01.006 |
| 中文关键词: 脑出血 自由基清除剂 肿瘤坏死因子α 白细胞介素1 |
| 英文关键词: Cerebral hemorrhage Free radical scavengers Tumor necrosis factor-alpha Interleukin-1〖FL |
| 基金项目:上海高校青年教师培养资助基金(ZZjdyx13102) |
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| 中文摘要: |
| 目的 探讨依达拉奉对急性脑出血患者血清肿瘤坏死因子α(TNF-α)和白细胞介素-1(IL-1)水平的影响,并观察其治疗效果。 方法 将首次发病的急性脑出血患者90例,按病例对照研究方法随机分为对照组45例、治疗组45 例,对照组是采用常规治疗,治疗组是在常规治疗基础上加用依达拉奉注射液30 mg+0.9%氯化钠注射液100 mL静脉滴注,2次/d,共14 d。比较两组患者于治疗前、后神经功能缺损程度(NIHSS)及日常生活活动量(ADL)评分,并进行疗效评定,检测患者血清TNF-α、IL-1水平的变化。 结果 治疗组在治疗后14 d NIHSS评分[(11.57±1.82)分]及ADL评分[(54.84±4.18)分]与对照组[(16.82±2.27)分、(45.13±3.93)分]相比,差异有统计学意义(均P<0.05) ；治疗组临床疗效明显优于对照组(P<0.05),其神经功能缺损程度明显改善,日常生活能力明显提高。治疗后,治疗组TNF-α[(13.06±2.90)ng/L]、IL-1[(4.31±2.23)ng/L]水平较对照组[(18.96±3.04)ng/L、(9.76±2.67)ng/L]比较,差异有统计学意义(均P<0.05) 。 结论 依达拉奉能减轻脑出血后炎性反应、清除自由基、改善神经功能缺损。 |
| 英文摘要: |
| Objective To explore the influence of edaravone for serum TNF-α and IL-1 and effects of in acute intracerebral hemorrhage.Mehtods Ninety cases with acute intracerebral hemorrhage were randomly divided into two groups:45 cases were treated with conventional therapy as control group,45 cases were treated with edaravone 30 mg and 0.9% NS 100 mL iv gtt,bid for 14 days as treatment group.The neurological impairment score (NIHSS) and activity of daily living(ADL) scale were evaluated and compared before and after treatment between two groups.The changes of TNF-α and IL-1 were detected before and after treatment between two groups.Results The NIHSS and ADL of treatment group were higher than those of control group 14 days later(P<0.05).The clinical effect of treatment group was significantly better than control group (P<0.05).Both neurological impairment score and capability of daily living were improved obviously.Serum TNF-α and IL-1 in treatment group were significantly decreased compared with control group after treatment(P<0.05).Conclusion Edaravone can alleviate inflammatory reaction,eliminate free radicals,improve the symptoms of neurological impairment for acute intracerebral hemorrhage. |
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