| 尹秋生,冬兰,赵倩.脂蛋白(a)对冠心病的致病性研究[J].中国临床保健杂志,2016,(1):22-23. |
| 脂蛋白(a)对冠心病的致病性研究 |
| The effect of lipoprotein (a) in the pathogenic mechanism of coronary heart disease |
| 投稿时间：2014-12-22 |
| DOI：10.3969/J.issn.1672-6790.2016.01.007 |
| 中文关键词: 冠心病 脂蛋白(A) 危险因素 |
| 英文关键词: Coronary disease Lipoprotein |
| 基金项目: |
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| 中文摘要: |
| 目的 分析血清脂蛋白(a)在冠心病发病中的作用。方法 将入选的495例患者以Lp(a)水平300 mg/L为切点,分为冠心病组(270例)、非冠心病组(225例),Lp(a)＞300 mg/L组(174例)、Lp(a)≤300 mg/L组(321例),分析Lp(a)在冠心病发病中的作用。结果 冠心病组血清Lp(a)均值为(310.09±253.73)mg/L,非冠心病组为(261.41±187.11) mg/L,冠心病组明显高于非冠心病患者,差异有统计学意义(P＜0.05)；Lp(a)＞300 mg/L组冠心病患病率明显高于Lp(a)≤300 mg/L组,差异有统计学意义(P＜0.05)；多因素Logostic 回归分析显示,Lp(a)、LDL-C和ApoB同为冠心病独立危险因素。服用他汀类药物者与未服用他汀类药物者Lp(a)水平差异无统计学意义(P＞0.05)。结论 Lp(a)是冠心病的独立危险因素,在冠心病的发病中起着重要的作用。 |
| 英文摘要: |
| Objective To analyze the effect of lipoprotein (a)in the pathogenic mechanism of coronary heart disease (CHD).Methods Four hundred and ninety-five individuals in this study were enrolled and divided into CHD group and non-CHD,and high level of LP(a) (＞300 mg/L) group and low level of LP(a) (≤300 mg/L) group,the effect of LP(a) in the pathogenic mechanism of CHD was analyzed.Results Levels of LP(a) was 310.09±253.73 mg/L in CHD group,and 261.41±187.11 mg/L in Non-CHD group.Difference in levels of LP(a) between the two groups was significant (P＜0.05).The incidence rate of CHD in the high level of LP(a) group was significantly higher than that in the low level of LP(a) group (P＜0.05).Logostic regression analysis showed that LP(a),LDL-C,and ApoB were independent risk factors for CHD.Difference in levels of LP(a) between patients with statin treatment and patients without statin treatment was no significant (P＞0.05).Conclusion Lp(a) is an independence risk factor for CHD,which may play important role in the pathogenic mechanism of CHD. |
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