| 聂鑫,王晓征,余益本,等.西格列汀治疗老年2型糖尿病患者的效果及对胰岛功能的影响[J].中国临床保健杂志,2016,(1):50-52. |
| 西格列汀治疗老年2型糖尿病患者的效果及对胰岛功能的影响 |
| Effect of DPP-4 inhibitor sitagliptin on β-cell function in elderly patients with type 2 diabetes |
| 投稿时间：2015-03-03 |
| DOI：10.3969/J.issn.1672-6790.2016.01.016 |
| 中文关键词: 糖尿病,2型 二肽基肽酶Ⅳ抑制剂 胰岛素抗体 胰岛素分泌细胞 |
| 英文关键词: Diabetes mellitus,type 2 Dipeptidyl-Peptidase IV Inhibitors Insulin antibodies Insulin-secreting cells 〖FL |
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| 中文摘要: |
| 目的 观察二肽基肽酶-4(DPP-4)抑制剂西格列汀治疗老年2型糖尿病患者的效果及对胰岛功能的影响。方法 选择老年2型糖尿病患者148例,采用完全随机分组法分为观察组(68例)和对照组(80例)。在原饮食、运动控制及用药基础上,观察组加用西格列汀片100 mg,每日1次,对照组加用瑞格列奈片1.0 mg,每日3次。检查治疗前及治疗6周后血脂、肝功能、肾功能、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、空腹胰岛素(FIns)、餐后2 h血糖(2h BG)和餐后2h胰岛素(2h Ins)水平,并计算胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)。结果 观察组中血糖控制率(HbA1c<7.0)为70.6%(48 /68),明显高于对照组53.8%(43/80)。两组经治疗6周后,与治疗前相比较,FBG、2h BG、HbA1c均降低,2h Ins升高,观察组HOMA-IR、三酰甘油下降,FIns、HOMA-β升高,差异有统计学意义(P＜0.05)。两组治疗前后肝、肾功能无明显变化,对照组血脂无明显变化(P>0.05)。与对照组治疗后比较,观察组治疗后FBG、2h BG、HbA1c、FIns 、2h Ins、HOMA-IR、HOMA-β差异均有统计学意义(P＜0.05) 。结论 DPP-4抑制剂西格列汀对老年2型糖尿病患者的疗效显著,改善胰岛β细胞功能,且安全性良好,对肝肾功能无显著不良影响。 |
| 英文摘要: |
| Objective To investigate the effect of dipeptidyl-peptidase IV(DPP-4)sitagliptin on β-cell function in elderly patients with type 2 diabetes.Methods 148 elderly patients with type 2 diabetes were randomly divided into the observation group (68 cases) and control group (80 cases).On the basis of the original diet,exercise and medication,the patients in the observation group was treated with sitagliptin tablets once a day and in the control group was treated with repaglinide tablets three times a day.The changes in blood lipids,liver function,renal function,hemoglobin A1c (HbA1c),fasting blood glucose (FBG),fasting insulin (FIns),2 h postprandial blood glucose (2h BG),2h postprandial insulin (2h Ins) were compared and the insulin resistance index (HOMA-IR) and function of islet βcell index (HOMA-β) were calculated before and after the 6-month treatment in the two groups.Results The blood glucose control rate (HbA1c<7.0) in the observation group was significantly higher than that in the control group (70.6% vs 53.8%).After 6 months treatment,levels of FBG,2h BG,HbA1c,HOMA-IR,triglycerides decreased and levels of 2hIns increased significantly compared with the basis. There were no significantly differences in liver function,renal function and blood lipids in the two groups (P>0.05).Conclusions DPP-4 inhibitor sitagliptin can reduce blood glucose effectively and improve the function of β-cell in elderly patients with type 2 diabetes. |
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