| 吴旭华,唐海沁,朱咏清,等.补充叶酸对社区原发性高血压患者同型半胱氨酸的影响[J].中国临床保健杂志,2016,(3):261-262. |
| 补充叶酸对社区原发性高血压患者同型半胱氨酸的影响 |
| Impact of folic acid supplement on plasma homocysteine levels in patients with essential hypertensive in the community |
| 投稿时间：2015-06-11 |
| DOI：10.3969/J.issn.1672-6790.2016.03.012 |
| 中文关键词: 高血压 半胱氨酸 叶酸 社区医学 |
| 英文关键词: Hypertension Cysteine Folic acid Community medicine 〖FL |
| 基金项目:安徽省卫生厅医学科研项目(13FR028) |
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| 中文摘要: |
| 目的 了解叶酸对于社区原发性高血压患者同型半胱氨酸水平的影响。方法 在两个功能社区内选取原发性高血压患者208名,采用随机数字法分配到干预组和对照组中,分别予以常规降压药物+叶酸(2.5 mg,2次/d)和常规降压药物,连续双盲治疗1年。于给药前测定两组Hcy水平并于治疗1年后进行随访同时测定Hcy水平。结果 干预组治疗前基线血浆Hcy水平及常规降压药物+叶酸干预1年后血浆Hcy水平为[(15.3±4.6)μmol/L,(9.1±2.7)μmol/L],干预后Hcy水平较干预前明显降低(P＜0.05)；对照组治疗前后血浆Hcy水平为[(14.2±4.8)μmol/L,(14.9±4.7)μmol/L],差异无统计学意义(P＞0.05),与干预组基线Hcy水平比较,差异也无统计学意义。结论 对于原发性高血压患者补充适当的叶酸能有效降低血Hcy水平,从而降低其心脑血管事件的发生率。 |
| 英文摘要: |
| Objective To investigate the impact of adding folic acid to the standard antihypertensive medication on plasma homocysteine(Hcy) levels in patients with essential hypertensive.Methods 208 essential hypertensive patients in community were randomly devided into two groups:group 1(standard medication),group 2(adding folic acid 2.5mg twice daily).Plasma Hcy level was deceted at baseline and one-year the therapy.Results There were no changes In group 1,the plasma Hcy level at baseline (14.2±4.8)μmol/L and the one-year therapy (14.9±4.7)μmol/L (all P>0.05).The plasma Hcy level was significantly decreased after the one-year treatment [(9.1±2.7)μmol/L VS. (15.3±4.6)μmol/L](all P<0.05) in group 2.Conclusions The supplementation of folic acid could significantly reduce plasma Hcy level,which may plays a positive role in the prevention of cardiovascular events. |
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