| 李彩艳,林凤平,赵辛元,等.血清铁蛋白与2型糖尿病的关系探讨[J].中国临床保健杂志,2016,(4):354-356. |
| 血清铁蛋白与2型糖尿病的关系探讨 |
| The relationship between serum ferritin and type 2 diabetes |
| 投稿时间：2015-03-18 |
| DOI：10.3969/J.issn.1672-6790.2016.04.006 |
| 中文关键词: 糖尿病, 2型 铁蛋白质类 葡萄糖代谢障碍 危险因素 |
| 英文关键词: Diabetes mellitus, type 2 Ferritins Glucose metabolism disorders Risk factors〖FL |
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| 中文摘要: |
| 目的 探讨血清铁蛋白 (SF)与2型糖尿病患者糖脂代谢、氧化应激和胰岛素抵抗的关系。 方法选取研究对象90例,其中2型糖尿病组32例、糖耐量减低(IGT)30例和健康对照组28例。收集和记录患者的一般资料,采用放免法测定SF和空腹胰岛素(FIns),全自动生化仪测定空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和血肌酐(SCr)等生化指标,高压液相法测定糖化血红蛋白(HbA1c),比色法测定超氧化物歧化酶(SOD)活性及丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)含量。结果 2型糖尿病组SF水平[(184.2±3.12) μg/L]高于IGT组[(171.5±2.61) μg/L],而IGT组高于健康对照组[(104.1±1.87) μg/L],差异有统计学意义(P<0.05)。SF与FIns、MDA、胰岛素抵抗指数、TG、TC和糖化血红蛋呈正相关(r=0.7145,P<0.05；r=0.5637,P<0.05；r=0.6358,P<0.05；r=0.8320,P<0.05；r=0.5283,P<0.01；r=0.6243,P<0.01)。与SOD活性、GSH-Px含量呈负相关(r=0.3413,P<0.05；r=0.3153,P<0.05)。结论 2型糖尿病患者体内铁贮备增多；铁超负荷促使氧化应激发生进而导致胰岛素抵抗。 |
| 英文摘要: |
| Objective To evaluate the relationship between serum ferritin (SF) and glucose and lipoprotein lipids metabolism, oxidative stress, insulin resistant in type 2 diabetes mellitus.Methods Ninty subjects were selected, including 28 controls,30 impaired glucose tolerance(IGT) and 32 type 2 diabetes. The general data (age, height, weight and family history) were collected. The levels of serum ferritin and fasting insulin(FIns) were detected by immuno-turbidimetry. Serum creatinine(SCr), lipid and fasting plasm glucose(FPG) were detected by automatic biochemical analazer. HbA1c was detected by high pressure liquid chromato-graphy. SOD, MDA and GSH-Px were detected by colorimetry.Results The levels of serum ferritin in patients with type 2 diabetes were significantly higher than that in impaired the glucose tolerance group and healthy subjects[(184.2±3.12) μg/L VS. (171.5±2.61) μg/L VS.(104.1±1.87) μg/L],there were statistical differences(P<0.05). Serum ferritin was positively correlated with FIns, index of insulin resistance(HOMA-IR) , TG,TC,HbA1c and MDA (r=0.7145,P<0.05；r=0.5637,P<0.05；r=0.6358,P<0.05；r=0.8320,P<0.05；r=0.5283,P<0.01；r=0.6243,P<0.01), and negatively correlated with SOD, GSH-Px(r=0.3413,P<0.05；r=0.3153,P<0.05).Conclusions The iron stores is increased in patients with type 2 diabetes,iron overload can cause oxidative stress and insulin resistance. |
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