| 戴朦,沈国栋,王俊,胡世莲,沈干.wnt/β-catenin信号通路相关蛋白在卵巢癌中的改变[J].中国临床保健杂志,2016,(4):441-444. |
| wnt/β-catenin信号通路相关蛋白在卵巢癌中的改变 |
| Change of the proteins associated with wnt/β-catenin signaling pathway in ovarian cancer |
| 投稿时间：2015-11-10 |
| DOI：10.3969/J.issn.1672-6790.2016.04.035 |
| 中文关键词: 卵巢肿瘤 Wnt信号通路 干细胞 |
| 英文关键词: Ovarian neoplasms Wnt signaling pathway Stem cells 〖FL |
| 基金项目:安徽省自然科学基金面上项目(1408085MH167)；安徽省科技攻关项目(1301042094) |
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| 中文摘要: |
| wnt/β-catenin信号通路在肿瘤发生发展中的作用已成为近年来研究的热点。wnt/β-catenin信号通路可以调控卵巢细胞的增殖、分化及恶性转化,由此介导肿瘤的发生和发展。研究显示,细胞膜上、胞质胞核内、细胞间及细胞外影响wnt/β-catenin通路蛋白的改变在卵巢癌形成中起重要作用。我们需要研究出更多在wnt/β-catenin通路中起关键作用的蛋白,并以此为靶标进行卵巢癌的治疗,将有助于研发出更加有效的治疗方案。 |
| 英文摘要: |
| The role of wnt/β-catenin Signaling pathway in tumor development has become a hotspot in recent years.Wnt/β-catenin signaling pathway could regulating proliferation,differentiation and malignant transformation of ovarian cells,and therefore mediated tumorigenesis and development.Studies have shown that change of the proteins which affecting wnt/β-catenin pathway on the cell membrane,cytoplasm,nucleus and outside the cell play an important role in the formation of ovarian cancer.More key proteins need to be study in the wnt / β-catenin pathway,and as a target for the treatment of ovarian cancer,which will help develop more effective treatment options. |
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