| 张伟,马维青,吕芳,胡国平,王国娟,孙春萍,刘皆.新诊断2型糖尿病伴腹型肥胖患者胰岛A和B细胞功能与血尿酸的相关性[J].中国临床保健杂志,2017,20(1):61-63. |
| 新诊断2型糖尿病伴腹型肥胖患者胰岛A和B细胞功能与血尿酸的相关性 |
| Correlation between islet alpha and beta cells functions and blood uric acid in the newly-diagnosed type 2 diabetes mellitus patients with abdominal obesity |
| 投稿时间：2016-08-15 |
| DOI：10.3969/J.issn.1672-6790.2017.01.019 |
| 中文关键词: 糖尿病,2型 尿酸 胰高血糖素分泌细胞 胰岛素分泌细胞 肥胖,腹部 |
| 英文关键词: Diabetes mellitus,type 2 Uric acid Glucagon-secreting cells Insulin-secreting cells Obesity,abdominal 〖FL |
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| 中文摘要: |
| 目的 探讨新诊断2型糖尿病(T2DM)伴腹型肥胖胰岛A和B细胞功能与血尿酸的相关性。方法 149例新诊断T2DM 患者,分为腹型肥胖组(AO)74 例和非腹型肥胖组(NAO)75 例。检测两组患者血尿酸和空腹及馒头餐试验后30、60、120、180 min 各时间点C 肽(CP)和胰高糖素水平。结果 AO组血尿酸与经对数转换后0、30、60、120、180 min时间点CP及0、30 min胰高糖素呈正相关(P＜0.05)；NAO组血尿酸与经对数转换后0、30、60、120、180 min各时间点CP正相关(P＜0.05),而与经对数转换后的各时间点胰高糖素均无相关性(P＞0.05)；两组合并后,血尿酸与经对数转换后0、30、60、120、180 min各时间点CP呈正相关(P＜0.05),与经对数转换后的0、30 min时间点胰高糖素呈正相关(P＜0.05)。结论 新诊断T2DM伴腹型肥胖胰岛A和B细胞功能与血尿酸具有相关性。 |
| 英文摘要: |
| Objective To discuss the correlation between the the islet alpha and beta cells function and blood uric acid in the newly-diagnosed T2DM patients with abdominal obesity.Method A total of 149 patients with newly diagnosed T2DM were divided into abdominal obesity group (74 patients) and non-abdominal obesity group (75 patients).Testing The blood uric acid,C-peptide(CP)and glucagon levels of patients were tested in the two groups in fasting and OGTT test after a time interval of 30 min,60 min,120 min,180 min.Results Blood uric acid in abdominal obesity group was positively correlated with log-transformed CP atthe time interval of 0 min,30 min,60 min,120 min,180 min and log-transformed glucagon atthe time interval of 0 min,30 min(P<0.05).Blood uric acid in non-abdominal obesity group was positively correlated with log-transformed C-P at the time interval of 0 min,30 min,60 min,120 min,180 min (P<0.05) while it had no correlaation with log-transformed glucagon at any time (P<0.05).After the combination of the two groups,the blood uric acid was positively correlated with log-transformed CP at the time interval of 0 min,30 min,60 min,120 min,180 min(P<0.05) and log-transformed Glucagon at the time interval of 0 min,30 min(P<0.05).Conclusion Islet alpha and beta Cells function of newly-diagnosed T2DM patients with abdominal obesity have correlation with blood uric acid. |
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