| 邹东华,吴原.RBM8a基因的基本生理功能和病理生理研究进展[J].中国临床保健杂志,2017,20(2):219-224. |
| RBM8a基因的基本生理功能和病理生理研究进展 |
| The primary physiological function and research progress of RBM8a |
| 投稿时间：2016-08-17 |
| DOI：10.3969/J.issn.1672-6790.2017.02.032 |
| 中文关键词: 外显子 蛋白质生物合成 突变 生理学过程 |
| 英文关键词: Protein biosynthesis Exons Mutation Physiological processes〖FL |
| 基金项目:国家自然科学基金项目(81560205)；广西自然科学基金项目(2012GXNSFAA276028)；广西自然科学基金项目(2016GXNSFCA380012) |
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| 中文摘要: |
| 真核生物mRNA的生物合成包括细胞核前体mRNA转录后修饰、mRNA的出核转运以及监控过程。剪接后的mRNA可与外显子连接复合体结合,外显子连接复合体(EJC)参与协调某些 mRNA生物合成的下游步骤。作为EJC核心蛋白之一的RBM8a,与其他核心因子一起参与无义介导的mRNA降解以及增强翻译过程。此外,RBM8a还参与其他的细胞进程,RBM8a基因突变或异常表达可导致生理异常及病变。 |
| 英文摘要: |
| The biosynthesis of eukaryotic mRNA includes post-translational modification of nuclear precursor mRNA ,nuclear translocation and monitoring of mRNA .The spliced mRNA can combine with Exon-Junction complex (EJC),and EJCs are involved in coordinating the downstream steps of some mRNA biosynthesis.One of the EJC ′s core protein,RBM8a,along with other core key factors are involved in nonsense- mediated mRNA degradation and enhance the translation process.In addition,RBM8a also takes part in other cellular process.RBM8a gene mutation or abnormal expression can lead to physiological abnormalities and lesions. |
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