| 陈伟,张江淮,肖蓓,陈雷,陶金辉.维持性血液透析患者钙磷代谢紊乱的异常因素分析[J].中国临床保健杂志,2017,20(3):244-246. |
| 维持性血液透析患者钙磷代谢紊乱的异常因素分析 |
| Abnormal factors analysis of calcium-phosphorus metabolism disorder in maintenance hemodialysis patients |
| 投稿时间：2017-02-20 |
| DOI：10.3969/J.issn.1672-6790.2017.03.005 |
| 中文关键词: 肾透析 钙代谢障碍 磷代谢障碍 甲状旁腺素 |
| 英文关键词: Renal dialysis Calcium metabolism disorders Phosphorus metabolism disorders Parathyroid hormone〖FL |
| 基金项目:安徽省自然科学基金项目(1708085MH191) |
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| 中文摘要: |
| 目的 探讨维持性血液透析患者钙磷代谢紊乱的异常因素。方法 对130例维持性血液透析患者的钙、磷浓度、钙磷浓度乘积及甲状旁腺激素(iPTH)进行测定,并与K/DOQI2003指南及KDIGO2009指南指标进行比较。结果 130例患者的血钙、血磷、钙磷乘积和iPTH以K/DOQI2003指南为标准,达标率分别为48.12%,48.23%,78.75%,20.28%；以KDIGO2009指南为标准,达标率分别为47.71%,28.74%,38.30%。血流量≥300 mL/min患者血磷水平较血流量<300 mL/min患者明显降低(t=2.892,P<0.05)。透析时间≥3年患者血钙、钙磷乘积和iPTH水平较透析时间<3年患者明显增高(t=2.479、5.681、3.012,P<0.05)。年龄≥50岁患者血磷、钙磷乘积水平较年龄<50岁患者明显降低(t=2.212、3.367,P<0.05)。结论 维持性血液透析患者存在钙磷代谢异常,控制水平仍然达不到指南要求。随着时间延长,钙磷代谢紊乱问题有所加重。 |
| 英文摘要: |
| Objective To analyze the abnormal factors of the disorder status of calcium-phosphorus metablism in maintenance hemodialysis patients.Methods Serum calciun,serum phosphorus,calcium-phosphorus product and iPTH were detected in 130 patients with maintenance hemodialysis,and compared with the indicators of K/DOQI2003 and KDIGO2009 guidelines.Results Eligibility rate about serum calcium and phosphorus and multiplication and the level of intact parathyroid hormone were 48.12%,48.23%,78.75%,20.28% respectively by the indicators of K/DOQI2003 guidelines.There were 47.71%,28.74%,38.30% respectively by the indicators of KDIGO2009 guidelines.The level of serum phosphorus was lower in patients whose blood flow over 300mL/min than patients whose blood flow less than 300mL/min(t=2.892,P<0.05).The level of serum calciun,calcium-phosphoris product and PTH were higher in patients whose hemodialysis vintage over 3 years than patients whose hemodialysis vintage lower 3 years(t=2.479,5,681,3.012,P<0.05).The level of serum phosphorus and calcium-phosphoris product were lower in patients whose age over 50 years than patients whose age lower 50 years(t=2.212,3.367,P<0.05).Conclusion There is abnormal calcium and phosphorus metabolism in the patients with maintenance hemodialysis,which don′t reach the K/DOQI and KDIGO guidelines.As the dialysis time increase,the abnormal mineral metabolism become more obviously. |
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