| 王洪群,王虎成,陈曦,王兴胜.N-乙酰半胱氨酸对慢性阻塞性肺疾病急性加重期作用的Meta分析[J].中国临床保健杂志,2017,20(3):253-257. |
| N-乙酰半胱氨酸对慢性阻塞性肺疾病急性加重期作用的Meta分析 |
| Effects of N-acetylcysteine on AECOPD:a systematic review of Meta analysis |
| 投稿时间：2016-10-12 |
| DOI：10.3969/J.issn.1672-6790.2017.03.008 |
| 中文关键词: 肺疾病,慢性阻塞性 乙酰半胱氨酸 Meta分析 |
| 英文关键词: Pulmonary disease,chronic obstructive Acetylcysteine Meta-analysis〖FL |
| 基金项目:重庆市卫生计生委医学科研计划项目(20142081) |
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| 中文摘要: |
| 目的 评价在常规治疗基础上加用N-乙酰半胱氨酸(NAC)对改善慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床症状及肺功能的作用。方法 计算机检索Cochrane图书馆、PubMed、EMbase、EBSCO host、中国知网和万方学术会议论文中关于在常规治疗基础上加用NAC治疗AECOPD中应用的随机对照试验(RCTs),检索时间为2000年1月至2015年4月。按照纳入与排除标准选择文献、评价文献质量,而后采用RevMan 5.30软件进行Meta分析。结果 共纳入8篇RCT,其中有7个研究表明NAC可以显著提高AECOPD的症状改善率(RR=1.21,95%CI:1.08~1.36,P=0.001)；有6个研究表明可以提高肺功能的第一秒钟用力呼气容积水平(WMD=0.33,95%CI:0.19~0.48,P<0.01)；有3个研究表明可以提高患者肺功能的最大肺活量水平(WMD=0.42,95%CI:0.29~0.54,P<0.01)；有4个研究表明可以提高患者动脉的血氧分压(WMD=7.30,95%CI:6.11~8.48,P<0.01)。结论 N-乙酰半胱氨酸治疗后可提高AECOPD患者的临床症状改善率,改善患者的第一秒用力呼气量和最大肺活量水平,增加动脉血氧分压。 |
| 英文摘要: |
| Objective In order to further understand the effects of conventional treatment combined with N-acetylcysteine (NAC) in AECOPD on the clinical symptoms and the values of FEV1 and FVC lung function.Methods The Cochrane library,PubMed,EMbase,EBSCO host,CNKI and Wanfang Data from January of 2000 to April of 2015 were searched to collect RCTs of conventional treatment combined with N-acetylcysteine in AECOPD.According to the inclusion and exclusion criteria,the quality of literature was evaluated,then the RevMan 5.30 software was used for Meta analysis for the standard RCTs.Results A total of eight RCTs were included,and seven studies showed that NAC could significantly increase the improvement rate (RR=1.21,5%CI:1.08-1.36,P=0.01).Six RCTs indicated that NAC could improve the FEV1 level of lung function (WMD=0.33,5%CI:0.19-0.48,P<0.01).Three RCTs showed that NAC could improve the FVC level of lung function (WMD=0.42,5%CI:0.29-0.54,P<0.01).Four RCTs showed that NAC could improve the patients of partial pressure of arterial oxygen (WMD=7.30,5%CI:6.11-8.48,P<0.01).Conclusion The conventional treatment combined with NAC can significantly improve the symptoms of AECOPD,FEV1 level of lung function,FVC level of lung Function and partial pressure of arterial oxygen of the patients with AECOPD. |
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