| 殷实,殷华,方向,丁西平,胡世莲.高龄慢性病患者血浆白蛋白与前白蛋白水平和外周血细胞免疫功能的相关性研究[J].中国临床保健杂志,2017,20(4):337-340. |
| 高龄慢性病患者血浆白蛋白与前白蛋白水平和外周血细胞免疫功能的相关性研究 |
| Plasma albumin,prealbumin level and the correlation with the cellular immune function in peripheral blood cell from elderly inpatients with chronic diseases |
| 投稿时间：2017-05-10 |
| DOI：10.3969/J.issn.1672-6790.2017.04.001 |
| 中文关键词: 慢性病 血清白蛋白 前白蛋白 T淋巴细胞 老年人,80以上 |
| 英文关键词: Chronic disease Serum albumin Prealbumin T-lymphocytes Aged,80 and over 〖FL |
| 基金项目:国家自然科学基金项目(81470879)；安徽省科技计划项目(1501041142)；肿瘤免疫与营养治疗安徽省重点实验室绩效项目(1606c08236) |
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| 中文摘要: |
| 目的 探讨高龄住院患者血浆前白蛋白(PAB)和白蛋白(ALB)水平与外周血细胞免疫功能之间的相关性。方法 选择住院高龄患者123例,按疾病类型分为感染性疾病和非感染性疾病,分为感染组64例、非感染组59例。免疫比浊法检测患者血浆PAB、ALB水平,细胞免疫芯片法检测外周血细胞T细胞亚群CD3、CD4、CD8细胞的数量以及CD4/CD8比值。比较两组差异,线性回归分析两组组内PAB/ALB水平与T淋巴细胞亚群之间的相关性。结果 感染组的PAB[(183.2±7.13)mg/L]明显低于非感染组[(228.9±6.93)mg/L]患者,而感染组和非感染组之间的ALB水平以及T细胞亚群均差异无统计学意义。感染组内PAB与CD3、CD4数量呈明显正相关(r=0.2551,P=0.0419；r=0.2585,P=0.0392),与CD8数量及CD4/CD8比值无明显相关性；而ALB与T细胞亚群也无显著相关。非感染组PAB、ALB水平与细胞免疫功能均无明显相关性。结论 PAB水平可作为预测老年感染性疾病患者细胞免疫功能的指标。 |
| 英文摘要: |
| Objective To compare the difference of plasma albumin,prealbumin level between elderly chronic disease inpatients with or without infection and analysize the correlation between plasma albumin/prealbumin and the cellular immune function in peripheral blood cell.Methods 123 elderly patients with chronic diseases during hospitalization in Geriatrics Department were enrolled in this study.The inpatients were assigned into 2 groups including non-infective group (n=59) and infective group (n=64).Plasma albumin and prealbumin level were measured by immunoturbidimetry assay.Cellular immune function including peripheral blood mononuclear cell surface T cell subsets CD3,CD4,CD8 and CD4/CD8 were examined by cell immuno-chip.Analysis of variance and Student’s t-test were used to compare the values from two groups.Linear-regression analysis was used to examine the correlation between plasma albumin/prealbumin level and the cellular immune function T cell subsets.Results Plasma prealbumin significantly decreased (183.2±7.13VS.28.9±6.93) while the albumin level and T cell subsets had no change in the inpatients from the infective group when compared with that in non-infective group.In the infective group,the plasma prealbumin was significantly correlated with the number of CD3 and CD4 (r=0.2551,P=0.0419;r=0.2585,P=0.0392) but had no relationship with the number of CD8 and CD4/CD8.While the plasma albumin had no correlation with CD3,CD4,CD8 and CD4/8.In the non-infective group,both plasma prealbumin and albumin levels had no association with the number of CD3,CD4,CD8 and CD4/CD8.Conclusion The plasma prealbumin measurement maybe a good predictor for cellular immune function in elderly inpatients with chronic diseases. |
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