| 丁芳,邱伟文.2型糖尿病眼底病变与动脉粥样硬化及脑钠肽水平的相关性分析[J].中国临床保健杂志,2017,20(6):700-703. |
| 2型糖尿病眼底病变与动脉粥样硬化及脑钠肽水平的相关性分析 |
| Correlation analysis of retinopathy and atherosclerosis,brain natriuretic peptide in type 2 diabetes mellitus |
| 投稿时间：2017-08-10 |
| DOI：10.3969/J.issn.1672-6790.2017.06.021 |
| 中文关键词: 糖尿病视网膜病变 动脉粥样硬化 利钠肽,脑 |
| 英文关键词: Diabetic retinopathy Atherosclerosis Natriuretic peptide,brain 〖FL |
| 基金项目:浙江省医药卫生一般研究计划(2015KYB451) |
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| 中文摘要: |
| 目的 研究分析2型糖尿病视网膜病变(DR)与动脉粥样硬化(AS)及N-末端脑钠素原(NT-proBNP)的相关性,以为临床研究和应用提供参考依据。方法 选取246例2型糖尿病住院患者,根据患者的视网膜病变情况分组,无视网膜病变者123例为非DR组,有视网膜病变者123例为DR组。分析比较患者的一般资料情况、病史、生活习惯、疾病情况、NT-proBNP水平、血脂、肾功能相关指标等情况。结果 DR组、非DR组并发AS患者分别为59例(47.97%)、28例(22.76%)。DR组、非DR组NT-proBNP水平异常偏高者分别62例(50.41%)、20例(16.26%)。DR组与非DR组在体质量指数(BMI)、血脂异常低密度脂蛋白胆固醇(LDL-C)、高脂血症(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、NT-proBNP水平比较,差异有统计学意义(P<0.05)；在性别、年龄、吸烟史、病程、血压比较,差异无统计学意义(P>0.05)。单因素分析结果显示,BMI、并发AS、血脂异常、TC、TG、HDL-C、LDL-C、NT-proBNP水平均为2型糖尿病患者DR的影响因素。经Logistic回归分析结果发现,T2DM患者视网膜病变与TC、TG、LDL-C和NT-proBNP水平呈正相关,与HDL-C水平呈负相关。结论 2型糖尿病眼底病变与AS、NT-proBNP水平有关,其中与TC、TG、LDL-C、NT-proBNP水平呈正相关,与HDL-C水平呈负相关。 |
| 英文摘要: |
| Objective To investigate the relationship among diabetic retinopathy(DR) and atherosclerosis(AS),brain natriuretic peptide(NT-proBNP) in patients with type 2 diabetes mellitus,and to to provide basis and reference for reasonable application.Methods A total of 246 patients with type 2 diabetes mellitus were enrolled.One hundred and and twenty-three cases without retinopathy were non-DR group and 123 cases with retinopathy were DR group according to the retinopathy of the patients.The general information,history,lifestyle,disease,serum NT-proBNP levels,blood lipids,renal function related indicators and so on of patients were compared.Results The patients with AS of DR group and non DR group was 59 (47.97%) and 28 (22.76%) respectively.The patients with high BNP of DR group and non-DR group was 62 cases(50.41%),20 cases(16.26%).The difference of BMI,TC,TG,HDL-C,LDL-C and NT-proBNP levels between two groups were statistically significant;the difference of sex,age,smoking history,Blood pressure between two groups were not statistically significant,P＞0.05.Univariate analysis showed that BMI,concurrent AS,dyslipidemia,TC,TG,HDL-C,LDL-C,NT-proBNP levels were the risk factors of DR in type 2 diabetes mellitus.The Logistic regression analysis showed that serum TC,TG,LDL-C and NT-proBNP level were positively correlated with retinal lesions,are negatively correlated with HDL-C level.Conclusion The fundus lesion of type 2 diabetes mellitus is related to the AS and NT-proB NP,and DR is positively correlated with the TC,TG,LDL-C and NT-proBNP,is negatively correlated with HDL-C. |
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