文章摘要
林陆韬,韦志,韦荣玮,黄芳葵,宋淑平.糖尿病合并心房颤动患者血清超敏C反应蛋白与同型半胱氨酸水平和颈动脉硬化的相关性[J].中国临床保健杂志,2018,21(2):203-205.
糖尿病合并心房颤动患者血清超敏C反应蛋白与同型半胱氨酸水平和颈动脉硬化的相关性
Correlation research between serum hs-CRP,Hcy levels and carotid artery atherosclerosis of patients with diabetes mellitus and atrial fibrillation
投稿时间:2017-10-17  
DOI:10.3969/J.issn.1672-6790.2018.02.017
中文关键词: 糖尿病,2型  心房颤动  颈动脉血栓形成  C反应蛋白质  半胱氨酸
英文关键词: Diabetes mellitus,type 2  Atrial fibrillation  Carotid artery thrombosis  C-Reactive protein  Cysteine
基金项目:广西壮族自治区科学技术厅资助课题(16217107)
作者单位E-mail
林陆韬 广西河池市第一人民医院心血管内科,546300 linlutao378@163.com 
韦志 广西河池市第一人民医院心血管内科,546300  
韦荣玮 广西河池市第一人民医院心血管内科,546300  
黄芳葵 广西河池市第一人民医院心血管内科,546300  
宋淑平 广西河池市第一人民医院心血管内科,546300  
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中文摘要:
      目的 探讨糖尿病合并心房颤动患者血清超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平与颈动脉粥样硬化之间的相关性。方法 选取361例糖尿病患者为研究对象,分别分为A组(糖尿病并心房颤动,120例)、B组(糖尿病并窦性心律,118例)、C组(单纯糖尿病,123例),A组依据心房颤动持续时间采用3P法分别分为A1组(阵发性心房颤动,43例)、A2组(持续性心房颤动,39例)、A3组(永久性心房颤动,38例)。检测上述各组血清hs-CRP、Hcy水平,颈动脉超声检查内膜中层厚度(IMT)及Crouse积分。结果 A组、B组、C组在体质量指数、吸烟、血脂异常、高血压及LVEF等方面比较,差异无统计学意义(P>0.05)。A组血清hs-CRP、Hcy水平明显高于B组、C组(P<0.05);B组血清hs-CRP、Hcy水平明显高于C组(P<0.05);A1组血清hs-CRP、Hcy水平明显低于A2组、A3组(P<0.05);A2组血清hs-CRP、Hcy水平明显低于A3组(P<0.05)。A组IMT、Crouse积分水平明显高于B组、C组(P<0.05);B组IMT、Crouse积分明显高于C组(P<0.05);A1组IMT、Crouse积分明显低于A2组、A3组(P<0.05);A2组IMT、Crouse积分明显低于A3组(P<0.05)。A组血清hs-CRP、Hcy、IMT、Crouse积分均与心房颤动持续时间成正相关。结论 血清hs-CRP、Hcy水平与糖尿病并心房颤动患者颈动脉粥样硬化严重程度有关,且随着心房颤动时间的持续,颈动脉粥样硬化程度越严重。
英文摘要:
      Objective To investigate the relationship between serum hs-CRP,Hcy and carotid atherosclerosis of patients with diabetes mellitus and atrial fibrillation.Methods A total of 361 diabetic patients in our hospital were selected as research object and divided into group A(diabetes mellitus and atrial fibrillation,120 cases),group B(diabetic sinus rhythm,118 cases),group C (simple diabetes mellitus,123 cases).Group A was divided into group A1 (paroxysmal atrial fibrillation,43 cases),A2 group (persistent atrial fibrillation,39 cases),A3 group (permanent atrial fibrillation,38 cases) according to the duration of atrial fibrillation.The serum hs-CRP,Hcy levels,carotid ultrasound IMT and Crouse score of each group were detected.Results There were no significant difference in body mass index,smoking,dyslipidemia,hypertension and LVEF between group A,group B and group C(P>0.05).The serum hs-CRP and Hcy levels of group A were significantly higher than those of group B and group C(P<0.05).The serum hs-CRP and Hcy levels of group B were significantly higher than those in group C (P<0.05).The hs-CRP and Hcy levels of group A1 were significantly lower than those of group A2 and group A3 (P<0.05).The hs-CRP and Hcy levels of group A2 were significantly lower than those of group A3 (P<0.05).The IMT and Crouse levels of group A were significantly higher than those of group B and group C (P<0.05).The IMT and Crouse scores of group B were significantly higher than those of group C (P<0.05).The IMT and Crouse levels of group A1 were significantly lower than those of group A2 and group A3 (P<0.05).The IMT and Crouse levels of group A2 were significantly lower than those of group A3(P<0.05).The serum hs-CRP,Hcy,IMT,Crouse of group A were positively correlated with the duration of atrial fibrillation.Conclusion Serum hs-CRP and Hcy levels are related to the severity of carotid atherosclerosis of patients with diabetes mellitus and atrial fibrillation.The severity of carotid atherosclerosis is more serious with the duration of atrial fibrillation.
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