文章摘要
汪文锐,胡何节,王晓天,方征东,孙小杰,葛新宝,程灿.中性粒细胞/淋巴细胞比值与D-二聚体在深静脉血栓诊断中的价值[J].中国临床保健杂志,2018,21(2):206-209.
中性粒细胞/淋巴细胞比值与D-二聚体在深静脉血栓诊断中的价值
The diagnostic value of NLR and D-dimmer in patients with deep venous thrombosis
投稿时间:2017-12-04  
DOI:10.3969/J.issn.1672-6790.2018.02.018
中文关键词: 静脉血栓栓塞  淋巴细胞  脱氧核糖核酸酶(嘧啶二聚体)  炎症
英文关键词: Venous thromboembolism  Lymphocytes  Deoxyribonuclease
基金项目:
作者单位E-mail
汪文锐 安徽医科大学附属省立医院、安徽省立医院血管外科,合肥 230001 wangwenrui1994@126.com 
胡何节 安徽医科大学附属省立医院、安徽省立医院血管外科,合肥 230001 hu.hejie@163.com 
王晓天 安徽医科大学附属省立医院、安徽省立医院血管外科,合肥 230001  
方征东 安徽医科大学附属省立医院、安徽省立医院血管外科,合肥 230001  
孙小杰 安徽医科大学附属省立医院、安徽省立医院血管外科,合肥 230001  
葛新宝 安徽医科大学附属省立医院、安徽省立医院血管外科,合肥 230001  
程灿 安徽医科大学附属省立医院、安徽省立医院血管外科,合肥 230001  
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中文摘要:
      目的 探讨中性粒细胞/淋巴细胞比值(NLR)和D-二聚体在下肢深静脉血栓(DVT)诊断中的价值。方法 选取DVT患者180例,其中男88例,女92例;健康对照组为216名健康体检者,其中男124例,女92例。分析两组白细胞计数、中性粒细胞计数、淋巴细胞计数、NLR和D-二聚体水平,并进行比较。结果 DVT组白细胞、中性粒细胞、NLR和D-二聚体水平显著高于健康对照组(P<0.001),而淋巴细胞计数比健康对照组明显降低(P<0.001)。Logistic分析显示:NLR、D-二聚体与深静脉血栓的发生呈正相关(P<0.05)。两者在深静脉血栓中的诊断敏感性分别为65.6%和95.6%,阴性预测价值分别为76.7%和96%, NLR的 ROC曲线下面积大小为0.871,D-二聚体的为0.963。结论 NLR和D-二聚体可作为下肢深静脉血栓的辅助诊断指标,NLR的阳性诊断价值较高。
英文摘要:
      Objective To investigate the diagnostic value of neutrophil to lymphocyte ratio(NLR) and D-dimmer in patients with deep venous thrombosis.Methods 180 patients with deep venous thrombosis (88 males,92 females) and 216 healthy controls(124 males,92 females) were retrospectively enrolled.The leukocytes,neutrophile,lymphocytes and D-dimmer of the two groups were detected and their NLR were calculated and compared.Results The counts of leukocytes and neutrophile and level of D-dimmer were remarkably higer in DVT than those in control group(P<0.05),while the counts of lymphocytes were lower in DVT than that in control group(P<0.05).Logistic analysis showed the level of NLR and D-dimmer was strongly correlated with deep venous thrombosis(P<0.05).Diagnostic sensitivity of NLR and D-dimmer was 65.6% and 95.6% in DVT,while negative predictive value was 76.7% and 96%.ROC curve analysis showed area under curve of NLR(0.871) and D-dimmer(0.963).Conclusion NLR and D-dimmer can be used as complementary diagnostic marker of deep venous thrombosis,and the positive diagnostic value of NLR is higher.
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