文章摘要
方妍妍,刘健,万磊,忻凌,董文哲,文建庭,宋倩,黄旦.健脾化湿清热通络药对活动期强直性脊柱炎患者血小板参数影响的数据挖掘[J].中国临床保健杂志,2018,21(2):210-213.
健脾化湿清热通络药对活动期强直性脊柱炎患者血小板参数影响的数据挖掘
The data mining research of the Spleen and Clearing-heat Know Luo with Medicine for the platelet parameters effect of activity period ankylosing spondylitis patients
投稿时间:2017-08-11  
DOI:10.3969/J.issn.1672-6790.2018.02.019
中文关键词: 脊柱炎,强直性  中草药  健脾  化湿  血小板计数  数据挖掘
英文关键词: Spondylitis,ankylosing  Drugs,Chinese herbal  Strengthening spleen  Dissipating dampness  Platelet count  Data mining
基金项目:安徽省科技攻关项目(1604a0802085);中央引导地方科技发展专项(财教〔2016〕1188);现代中医内科应用基础与开发研究安徽省重点实验室(财教〔2016〕518);2015年技术创新服务体系专项(财教〔2015〕1551);中医药行业科研专项(201307001)
作者单位E-mail
方妍妍 安徽中医药大学研究生院,合肥 230038 675867310@qq.com 
刘健 安徽中医药大学第一附属医院风湿免疫科 liujianahzy@126.com 
万磊 安徽中医药大学第一附属医院风湿免疫科  
忻凌 安徽中医药大学第一附属医院风湿免疫科  
董文哲 安徽中医药大学研究生院,合肥 230038  
文建庭 安徽中医药大学研究生院,合肥 230038  
宋倩 安徽中医药大学研究生院,合肥 230038  
黄旦 安徽中医药大学研究生院,合肥 230038  
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中文摘要:
      目的 应用关联规则和统计学方法分析应用健脾化湿清热通络药治疗活动期强直性脊柱炎对患者血小板参数及炎症指标、免疫指标的影响,以期为优化临床用药提供依据。方法 整理2012年6月至2016年12月安徽中医药大学第一附属医院录入的1011例强直性脊柱炎患者的资料。采用 SPSS 21.0软件和SPSS Clementine 11.1 软件分析治疗前后实验室指标情况并对中药进行关联规则分析和聚类分析。结果 (1)治疗强直性脊柱炎的常用药物分为4大类:健脾利湿药、祛风除湿药、活血化瘀药、清热解毒药。(2)健脾化湿清热通络药治疗活动期强直性脊柱炎后,患者血小板参数及炎症指标、免疫指标均有所改善。(3)中药与实验室指标关联分析发现,鸡血藤、陈皮、伸筋草、豨莶草、白花蛇舌草、蒲公英、黄芩与血小板参数相关。(4)当欧式距离为20时,可将药物分为3大类。第1类:含桃仁、红花、丹参、陈皮、薏苡仁、威灵仙、茯苓、山药、蒲公英、白花蛇舌草、泽泻、豨莶草12味药。第2类:含独活、伸筋草、鸡血藤3味药。第3类:含黄柏、知母、黄芩、桑寄生、川芎5味药。结论 健脾化湿清热通络药可改善活动期强直性脊柱炎患者的血小板参数,可降低患者的炎症指标及调节其免疫指标。
英文摘要:
      Objective To applicate the association rules and statistical methods to analyze its applied spleen wet heat li rheumatism lead of t2dm with medicine treatment activity in patients with ankylosing spondylitis platelet parameters and inflammation index,the influence of the immune index,in order to provide the basis for optimization of clinical drug use.Methods To sort out the first affiliated hospital of anhui medical university electronic medical records system data entry of ankylosing spondylitis patients.Using SPSS 21.0 software and SPSS 11.1 software clementine to analyse laboratory indexes before and after treatment and the traditional Chinese medicine association rule analysis and clustering analysis.Results (1)The treatment of ankylosing spondylitis li rheumatism lead of the commonly used drugs is divided into four categories:spleen lishi medicine medicine,promoting blood circulation to remove blood stasis drugs,functions of dehumidification,heat of poison.(2) Spleen wet heat t2dm medicine after active treatment of ankylosing spondylitis,patients with platelet parameters and inflammation,immune index were improved.(3)Traditional Chinese medicine and laboratory index correlation analysis found,caulis spatholobi,dried tangerine or orange peel,common clubmoss herb,glandularstalk st.paulswortherb/common st.paulswort grass,spreading hedyotis herb,dandelion,radix scutellariae and platelet parameters related to the common clubmoss herb & dandelion is associated with the PLT.(4) When the Euclidean distance of 20,drugs can be divided into three broad categories.Class 1:peach kernel,safflower,red sage root,dried tangerine or orange peel,coix seed,clematis root,tuckahoe,yam,dandelion,spreading hedyotis herb,alisma,glandularstalk st.paulswortherb/common st.paulswort grass 12 herbs.Class 2:living alone,common clubmoss herb,caulis spatholobi 3 herbs.Class 3:including cortex phellodendri,rhizoma anemarrhenae,radix scutellariae,mulberry parasitism,rhizoma ligustici wallichii 5 herbs.Conclusion Spleen,wet heat t2dm medicine can improve activity platelet parameters of patients with ankylosing spondylitis,reduce inflammatory indexes and adjust the immune indexes of patients.
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