| 邢艳阳,李中南,邢宇婷,窦德梅.中药健脾方对糖尿病大鼠肾组织骨桥蛋白及肾脏病理的影响[J].中国临床保健杂志,2018,21(2):225-228. |
| 中药健脾方对糖尿病大鼠肾组织骨桥蛋白及肾脏病理的影响 |
| Effect of Jianpi Decoction on osteopontin and renal pathology in renal tissue of diabetic rats |
| 投稿时间：2017-10-17 |
| DOI：10.3969/J.issn.1672-6790.2018.02.023 |
| 中文关键词: 糖尿病肾病 健脾 骨桥蛋白质 病理状态,体征和症状 |
| 英文关键词: Diabetic nephropathies Strengthening spleen Osteopontin Pathological conditions,signs and symptoms |
| 基金项目:国家中医临床研究基地业务建设科研专项立项课题(JDZX2012004) |
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| 中文摘要: |
| 目的 探讨中药健脾方对糖尿病大鼠肾组织骨桥蛋白(OPN)的表达及对肾脏病理的影响。方法 取50只健康雄性大鼠随机分成健康对照组及实验组,实验组喂养高脂饲料,采取链脲佐菌素(STZ)一次性腹腔注射35 mg/kg造模。将成模大鼠随机分成模型组、吡咯列酮组、中药健脾方组(简称中药组)。各给药组予相应药物灌胃8周,在第2、4、8周末测血糖,8周末测血脂,并做肾组织OPN的检测及肾脏病理。结果与模型组对比,中药组、吡格列酮组大鼠血脂、各时段血糖水平降低(P＜0.01)；模型组大鼠肾组织病变显著,OPN的表达明显升高,各给药组大鼠肾组织病变明显减轻,OPN表达降低,与模型组比较,差异有统计学意义(P＜0.05或P＜0.01)。结论 中药健脾方可能通过降低肾组织 OPN 的高表达,减轻糖尿病大鼠肾组织的损伤。 |
| 英文摘要: |
| Objective To investigate the effect of Jianpi recipe on the osteopontin expression and renal pathology of diabetic rats.Methods Fifty healthy male rats were randomly divided into normal control group and experimental group.The experimental group was fed with high fat diet.And streptozotocin (STZ) was injected intraperitoneally with 35mg/kg to establish diabetes model.Then we randomly divided successful modeling rats into model group,pyrrolidone group and traditional Chinese medicine group.The corresponding drugs were given to each group for 8 weeks.After 2nd,4th,8th week of intervention,the blood glucose in rats were determined.After 8th week,we measured blood lipids,did kidney pathology and renal tissue osteopontin (OPN).Results Compared with the model group,the levels of blood glucose and blood lipid in the Chinese medicine group and pioglitazone group were decreased (P<0.05 or P<0.01).The model group had significant renal pathological changes,and the expression of OPN was significantly increased.The renal tissue lesion in each treatment group was significantly reduced,and the expression of OPN in renal tissue was decreased,which had no significant difference compared with the model group (P＜0.05 or P<0.01).Conclusion Traditional Chinese medicine Jianpi prescription plays a role in protecting kidney for diabetic rats by decreasing the high expression of OPN in renal tissue. |
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