文章摘要
郦巧莲,陈培锋,王文红,李秋,黄虎威,王章达,宣林烽,石江联.慢性阻塞性肺疾病患者呼出气一氧化氮检测与外周血白细胞和C反应蛋白的相关性[J].中国临床保健杂志,2018,21(2):255-257.
慢性阻塞性肺疾病患者呼出气一氧化氮检测与外周血白细胞和C反应蛋白的相关性
Study on the correlation between FeNO detection and peripheral blood leukocyte and CRP in COPD patients
投稿时间:2017-10-17  
DOI:10.3969/J.issn.1672-6790.2018.02.030
中文关键词: 肺疾病,慢性阻塞性  一氧化氮  白细胞  C反应蛋白质
英文关键词: Pulmonary disease,chronic obstructive  Nitric oxide  Leukocytes  C-reactive protein,
基金项目:浙江绍兴市青年科技项目(2016QN016)
作者单位E-mail
郦巧莲 浙江诸暨市人民医院呼吸内科,311800 lql2009zs@126.com 
陈培锋 浙江诸暨市人民医院呼吸内科,311800  
王文红 浙江诸暨市人民医院呼吸内科,311800  
李秋 浙江诸暨市人民医院呼吸内科,311800  
黄虎威 浙江诸暨市人民医院呼吸内科,311800  
王章达 浙江诸暨市人民医院呼吸内科,311800  
宣林烽 浙江省诸暨市第六人民医院  
石江联 浙江省诸暨市第六人民医院  
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中文摘要:
      目的 探讨慢性阻塞性肺疾病(COPD)患者治疗中使用呼出气一氧化氮(FeNO)检测对患者的临床指导意义。方法 回顾性分析120例COPD患者的临床资料,将其作为观察组,其中明确为继发细菌感染引起疾病加重者40例(A组),无明确细菌感染依据但患者咳嗽气促症状未得到改善者40例(B组),无明确细菌感染依据患者咳嗽气促症状得到有效改善者40例(C组),对所有患者进行FeNO检测。观察比较各组患者的外周血白细胞、C反应蛋白(CRP)水平与FeNO检测之间的相关性,并给予及时的治疗方案改变。另选择120例未行FeNO检测的COPD患者作为对照组。对比分析观察组与对照组患者的重症发作住院次数与住院费用。结果 A组患者FeNO水平低于B组而高于C组(P<0.05),白细胞计数与CRP明显升高于其他两组(P<0.05);FeNO水平B组患者最高,C组患者最低(P<0.05)。同时,观察组患者的住院次数与住院费用均少于对照组(P<0.05)。结论 COPD患者稳定期应用吸入剂治疗中进行FeNO检测和血常规、CRP的监测,可以及时观察到患者长期吸入糖皮质激素治疗期间合并继发感染的风险,及时干预,从而减少重症发作住院的次数,减轻患者的疾病痛苦,减少医疗费用。
英文摘要:
      Objective To evaluate the efficiency of FeNO detection in the diagnosis and treatment of patients with chronic obstructive pulmonary disease (COPD).Method One hundred and twenty patients with COPD treated in our hospital were retrospectively reviewed and divided into 3 groups.Group A consisted of 40 patients,who were complicated with bacterial infection.40 patients in group B presented with cough and psoriatic symptoms,but without remarkable bacterial infection,and the symptoms weren′t improved when sampling.40 patients in group C got improvement in cough and psoriatic symptoms and no evidence of bacterial infection.Another 120 patients with COPD were selected as control group,who didn′t receive FeNO testing.The frequency and total cost of hospitalization were compared between the observation and control group.Results There was no significant difference between the level of FeNo in Group A and the normal level (P>0.05),while the level of white blood cell count and CRP were increased significantly (P<0.05).The level of FeNO in group B was significantly higher than that in normal group (P<0.05),while the white blood cell count and CRP had no significant change(P>0.05).The level of FeNO in group C was significantly decreased compared with normal level (P<0.05).The frequency and total cost of hospitalization in the observation group were lower than those in the control group (P<0.05).Conclusion Concurrent infection can be timely revealed in patients with COPD who are treated by long-term inhaled glucocorticoid.The frequency and cost of hospitalization of these patients can be significantly decreased upon timely measurements taken.
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