文章摘要
王冉冉,张英俊,马东星.氯吡格雷治疗不稳定型心绞痛患者的临床效果及对视觉模拟评分的影响[J].中国临床保健杂志,2018,21(3):338-341.
氯吡格雷治疗不稳定型心绞痛患者的临床效果及对视觉模拟评分的影响
Clinical observation of clopidogrel in treating patients with unstable angina pectoris and its influence on VAS score
投稿时间:2018-01-17  
DOI:10.3969/J.issn.1672-6790.2018.03.014
中文关键词: 心绞痛,不稳定型  氯吡格雷  阿托伐他汀钙  疼痛测定
英文关键词: Angina,unstable  Clopidogrel hydrogen  Atorvastatin calcium  Pain measurement〖FL
基金项目:
作者单位E-mail
王冉冉 中国武警总医院心内科,北京 100039 appleplace@126.com 
张英俊 北京大学首钢医院神经外科  
马东星 中国武警总医院心内科,北京 100039 qdhet885@163.com 
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中文摘要:
      目的 探讨氯吡格雷在不稳定型心绞痛患者中的临床效果及对视觉模拟评分(VAS)的影响。方法 选取不稳定型心绞痛患者90例,按随机数字法分为对照组(45例)和观察组(45例)。对照组采用阿托伐他汀钙治疗,观察组在对照组基础上联合氯吡格雷治疗,采用VAS量表对两组治疗前、治疗后1个月、2个月、3个月VSA评分进行评估,利用超声心动图测定两组治疗前、后左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)及左心室射血分数(LVEF)水平,比较两组临床疗效及对VAS评分的影响。结果 观察组有效率为95.56%,与对照组82.22%比较,差异有统计学意义(χ2=7.812,P<0.05);观察组治疗后1个月VSA评分(3.51±1.02)分、2个月(1.15±0.57)分、3个月(0.99±0.12)分,均低于对照组1个月VSA评分(5.01±1.31)分、2个月(3.57±0.95)分、3个月(1.46±0.64)分(t=19.581、20.448、18.396,均P<0.05);观察组治疗后3个月左心室舒张末期内径(51.23±5.06)mm、左心室收缩末期内径(41.23±5.93)mm,均低于对照组左心室舒张末期内径(56.46±5.12)mm、左心室收缩末期内径(48.45±6.04)mm(t=19.946、11.291,P<0.05);观察组治疗后3个月左心室射血分数[(53.31±4.98)%]高于对照组[(45.83±4.63)%],t=10.993,P<0.05。结论氯吡格雷可改善不稳定型心绞痛患者心功能,降低VAS评分。
英文摘要:
      Objective To investigate the clinical effect of clopidogrel in treating patients with unstable angina and its effect on Visual Analogue Scale (VAS).Methods A total of 90 patients with unstable angina pectoris were randomly divided into a control group (45 cases) and an observation group (45 cases).The control group was treated with atorvastatin calcium,and the observation group was treated with clopidogrel on the basis of the control group.The VAS scale was used to evaluate the VSA scores before and after the treatment of the two groups,1 month,2 months,and 3 months.The left ventricular end-diastolic dimension (LVEDD),left ventricular end-systolic diameter (LVESD),and left ventricular ejection fraction (LVEF) levels were determined before and after treatment using echocardiography.The clinical efficacy and VAS were compared between the two groups.The effect of the score.Results The efficiency in observation group was 95.56% compared with 82.22% in the control group,the difference was statistically significant (χ2=7.812,P<0.05);the observation group 1 month after treatment VSA score (3.51±1.02) points,2 months (1.15 ±0.57) points and three months (0.99±0.12) points,all lower than the control group's one-month VSA score (5.01±1.31) points,two months (3.57±0.95) points,and three months (1.46±0.64) (t=19.581,0.448,8.396.P<0.05);the left ventricular end-diastolic diameter (51.23±5.06)mm and left ventricular end-systolic diameter (41.23±5.93)mm were lower in the observation group 3 months after treatment.In the control group,the left ventricular end-diastolic diameter (56.46±5.12)mm,left ventricular end-systolic diameter (48.45±6.04)mm(t=19.946,t=11.291.P<0.05);the left ventricular ejection fraction of the observation group 3 months after treatment ( 53.31±4.98)% was higher than the control group (45.83±4.63)%(t=10.993,P<0.05).Conclusion The use of clopidogrel in treating patients with unstable angina has significant effect in improving the heart function and reducing the VAS score.
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