文章摘要
赵梁燕,高倩,陈将南,陶学芳,潘晔.2型糖尿病患者外周血液指标的变化及其与颈动脉硬化的相关性[J].中国临床保健杂志,2018,21(3):360-363.
2型糖尿病患者外周血液指标的变化及其与颈动脉硬化的相关性
Changes in peripheral blood NLR,serum RBP4,sdLDL and ANGPTL4 in patients with T2DM and the relationship with carotid atherosclerosis
投稿时间:2018-03-14  
DOI:10.3969/J.issn.1672-6790.2018.03.020
中文关键词: 糖尿病,2型  颈动脉疾病  颈动脉内膜中膜厚度  视黄醇结合蛋白质类
英文关键词: Diabetes mellitus,type 2  Carotid artery diseases  Carotid intima-media thickness  Retinol-binding proteins〖FL
基金项目:
作者单位E-mail
赵梁燕 浙江绍兴市立医院呼吸感染科,312000 358364887@qq.com 
高倩 浙江绍兴市立医院内分泌科,312000  
陈将南 浙江绍兴市立医院检验科,312000  
陶学芳 浙江绍兴市立医院呼吸感染科,312000  
潘晔 浙江绍兴市立医院内分泌科,312000  
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中文摘要:
      目的 探讨2型糖尿病(T2DM)患者外周血中性粒细胞与淋巴细胞比值(NLR)、血清视黄醇结合蛋白4(RBP4)、小而密低密度脂蛋白(sdLDL)、血管生成素样蛋白4(ANGPTL4)的变化及与患者发生颈动脉粥样硬化的关系。方法 选取确诊的单纯T2DM患者60例(T2DM组)、60例T2DM合并颈动脉粥样硬化患者(CAS组)、60例健康对象(对照组),检测并比较三组研究对象的NLR、RBP4、sdLDL、ANGPTL4。结果 CAS组患者的RBP4、sdLDL测定值显著的高于T2DM组、对照组(均P<0.05),CAS组患者的血清ANGPTL4、NLR显著的低于T2DM组、对照组(均P<0.05);T2DM组患者的RBP4、sdLDL测定值显著的高于对照组(均P<0.05),T2DM组患者的血清ANGPTL4、NLR显著的低于T2DM组、对照组(均P<0.05);CAS组患者的RBP4、sdLDL测定值与内膜中层厚度(IMT)呈显著的正相关关系(P<0.05),CAS组患者的ANGPTL4测定值与IMT呈显著的负相关关系(P<0.05),CAS组患者的NRL测定值与IMT无明显的相关关系(P>0.05)。结论 2型糖尿病患者血清RBP4、sdLDL、ANGPTL4水平变化与其IMT增厚有关。
英文摘要:
      Objective To explore the relationship between peripheral blood leukocytes,lymphocyte ratio (NLR),serum retinol binding protein 4 (RBP4),small and dense low density lipoprotein (sdLDL),angiopoietin like protein 4 (ANGPTL4) and carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM).Methods Sixty T2DM patients,60 T2DM patients with carotid atherosclerosis and 60 healthy subjects were selected as T2DM group,CAS group and control group.The NLR,RBP4,sdLDL,ANGPTL4 of three group were detected and compared.Results The RBP4 and sdLDL of CAS group was significant higher than that of T2DM group and control group (P<0.05),but ANGPTL4 and NLR were significantly lower than T2DM group and the control group (P<0.05).The RBP4,sdLDL of T2DM group were significantly higher than the control group (P<0.05),but the ANGPTL4 and NLR were significantly lower than the control group (P<0.05).The RBP4,sdLDL were significantly and positively correlated with the IMT (P<0.05) in CAS group,but the ANGPTL4 wassignificant negative correlated with IMT (P<0.05).Conclusion The blood NLR,RBP4,sdLDL and ANGPTL4 in T2DM patients with carotid atherosclerosis change significantly,and the RBP4,sdLDL and ANGPTL4 had correlation with IMT.
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