| 王晓丽,唐海沁,郎翠凤,等.心房颤动患者华法林抗凝治疗效果和安全性的Meta分析[J].中国临床保健杂志,2018,21(4):437-441. |
| 心房颤动患者华法林抗凝治疗效果和安全性的Meta分析 |
| Meta analysis of anticoagulant effect and safety of warfarin in patients with atrial fibrillation |
| 投稿时间：2017-07-28 |
| DOI：10.3969/J.issn.1672-6790.2018.04.002 |
| 中文关键词: 心房颤动 华法林 阿司匹林 Meta分析 |
| 英文关键词: Atrial fibrillation Warfarin Aspirin Meta-analysis 〖FL |
| 基金项目:国家中医药管理局国家中医临床研究基地业务建设科研专项课题(IDZX2015133) |
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| 中文摘要: |
| 目的 评价华法林抗凝治疗心房颤动患者疗效和安全性。方法 计算机检索Cochranelibrary,Pubmed,EMBASE,万方数据库,中国学术期刊全文数据库(CNKI),中国生物医学文献数据库(CBM),维普数据库(VIP)至2017年4月,收集有关华法林抗凝治疗心房颤动患者的疗效和安全性随机对照试验(RCT),按纳入标准及排除标准选择文献,提取资料,并进行方法学质量评估,使用Stata 12.0软件进行Meta分析。结果 最终纳入20项研究,研究对象2194例。Meta分析结果:华法林组的抗凝效果优于阿司匹林:脑梗死发生率低于阿司匹林组(OR=0.15,5％CI:0.08～0.29,P＜0.05)；脑卒中发生率低于阿司匹林组(OR=0.35,5％CI:0.22～0.57,P＜0.05)；外周动脉栓塞发生率低于阿司匹林组(OR=0.42,5％CI:0.25～0.71,P=0.001)；死亡发生率低于阿司匹林组(OR=0.28,5％CI:0.14～0.59,P=0.001)；华法林组与阿司匹林组出血事件发生率差异无统计学意义(OR=0.90,5％CI:0.66～1.22,P=0.488)。结论 华法林的安全性与阿司匹林相似,但华法林对于心房颤动患者的疗效优于阿司匹林。 |
| 英文摘要: |
| Objective To evaluate anticoagulant effect and safety of warfarin in patients with atrial fibrillation.Methods The literature of randomized and controlled trials(RCT)about anticoagulant effect and safety of warfarin in patients with atrial fibrillation were retrieved from Cochrane Library,Pubmed,EMBASE,WANFANG, CNKI,CBM and VIP(by April,2017),and documents were selected by inclusion criteria and exclusion criteria,extracted materials was given methodological quality evaluaion.Meta analysis was conducted by Stata12.0 software.Results There were 20 RCT and 2194 patients were included.Meta analysis showed that the anticoagulant effect of warfarin was better than that of aspirin: incidence rate of cerebral infarction of warfarin was lower than that of aspirin(OR=0.15,5％CI:0.08-0.29,P＜0.05),incidence rate of stroke of warfarin was lower than that of aspirin(OR=0.35,5％CI:0.22-0.57,P＜0.05),incidence rate of peripheral arterial embolism of warfarin was lower than that of aspirin(OR=0.42,5％CI:0.25-0.71,P=0.001).incidence of mortality of warfarin was lower than that of aspirin(OR=0.28,5％CI:0.14-0.59,P=0.001),and there was no significant difference of safety between warfarin and aspirin(OR=0.90,5％CI:0.66-1.22,P=0.488).Conclusion The safety of warfarin and aspirin is equal,but the therapy effect of warfarin is better than that of aspirin. |
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