| 程仁力,尚亚东,孙彤,吕秀英,蒋慧娟.强化他汀药物预防经皮冠状动脉介入术后造影剂肾病发生的临床观察[J].中国临床保健杂志,2018,21(4):514-517. |
| 强化他汀药物预防经皮冠状动脉介入术后造影剂肾病发生的临床观察 |
| Clinical observation of strengthening statins on the prevention of radiographic contrast nephropathy after percutaneous coronary intervention |
| 投稿时间：2017-11-10 |
| DOI：10.3969/J.issn.1672-6790.2018.04.020 |
| 中文关键词: 急性肾损伤 血管成形术,气囊,冠状动脉 羟甲基戊二酰基CoA还原酶抑制剂 |
| 英文关键词: Acute kidney injury Angioplasty,balloon,coronary Hydroxymethylglutaryl-CoA reductase inhibitors 〖FL |
| 基金项目:安徽省宿州市科技计划项目(20150208) |
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| 中文摘要: |
| 目的 探讨强化他汀药物治疗对于经皮冠状动脉介入术(PCI)后造影剂肾病的预防。方法 选取行PCI治疗的急性ST段抬高型心肌梗死中老年患者73例,采用随机数字表的方法将患者分入阿托伐他汀钙40 mg组(常规组)和阿托伐他汀80 mg组(强化组),观察患者血肌酐(Scr)及胱抑素C(CysC)的变化情况,并记录造影剂肾病的发生例数。结果 两组患者造影剂肾病的发生率分别为21.1%和2.99%,差异有统计学意义(P＜0.05)；术后第1天,两组Scr变化差异无统计学意义(P＞0.05),CysC变化差异有统计学意义(P＜0.05)；术后第3天,两组Scr和CysC变化均差异有统计学意义(P＜0.05)。结论 强化他汀药物能有效预防PCI后造影剂肾病的发生。 |
| 英文摘要: |
| Objective To explore the effect of fortified statin on radiographic contrast nephropathy after percutaneous coronary intervention.Methods A total of 73 middle and old aged patients with acute ST-segment elevation myocardial infarction who underwent PCI in our hospital were randomized to the atorvastatin calcium 40 mg group(routine Group) and atorvastatin 80 mg group(fortified group).The changes of serum creatinine(Scr) and cysteine C(CysC) were observed and the number of cases of radiographic contrast nephropathywas recorded.Results The incidence of radiographic contrast nephropathy was 21.1% and 2.99% in the two groups respectively, the difference was statistically significant(P＜0.05).On the first day after operation,there was no significant difference in Scr between two groups(P＞0.05), and the change of CysC was statistically significant(P＜0.05).On the third day after operation,the changes of Scr and CysC were statistically significant(P＜0.05).Conclusion Intensive statins therapy can prevent the occurrence of radiographic contrast nephropathy after PCI. |
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