| 王珺,王吉,张捷,欧龙,杨婷,谢潇.口腔溃疡含片治疗复发性阿弗他溃疡效果的系统评价[J].中国临床保健杂志,2018,21(6):752-756. |
| 口腔溃疡含片治疗复发性阿弗他溃疡效果的系统评价 |
| A systematic review on the clinical efficacy of oral ulcer tablets in the treatment of recurrent aphthous oral ulcers |
| 投稿时间：2018-07-02 |
| DOI：10.3969/J.issn.1672-6790.2018.06.008 |
| 中文关键词: 口腔溃疡 投药,局部 治疗结果 药物相关性副作用和不良反应 评价研究 |
| 英文关键词: Oral ulcer Administration,topical Treatment outcome Drug-related side effects and adverse reactions Evaluation studies 〖FL |
| 基金项目:国家自然科学基金面上项目(81271191) |
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| 摘要点击次数: 5825 |
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| 中文摘要: |
| 目的 系统评价口腔溃疡含片治疗复发性阿弗他溃疡的有效性和安全性。方法 计算机检索PubMed、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普数据库(VIP)、万方科技数据库关于口腔溃疡含片治疗复发性阿弗他溃疡的临床随机对照试验(各数据库检索时间均从创建至2017年10月),将纳入的文献进行方法学质量评价,利用RevMan5.2软件进行Meta分析。结果 共纳入12篇文献,包括1751例患者。Meta分析结果显示,口腔溃疡含片总有效率、溃疡愈合时间与对照组相比均性差异有统计学意义(P＜0.05),总有效率RR(95%CI)为1.21(1.14~1.29)；溃疡愈合时间SMD(95%CI)为-3.33(-6.05~-0.61)；两者不良反应率相比,差异无统计学意义(P＞0.05),RD(95%CI)为-0.03(-0.05~0.00)。结论 基于现有临床资料证据,口腔溃疡含片用于复发性阿弗他溃疡疗效确切,但这一结论尚需更多大样本高质量的临床随机对照试验加以证实。 |
| 英文摘要: |
| Objective To evaluate the efficacy and safety of oral ulcer tablets in the treatment of recurrent aphthous oral ulcers.Methods The randomized controlled trials (RCTs) of treating RAU with oral ulcer tablets were retrieved from PubMed,CNKI,CBM,VIP and Wanfang (from establish to Octled tr,and the methodological quality of included literatures was evaluated.Then Meta analyses were performed with RevMan 5.2 software.Results a total of 12 articles were included,including 1751 patients.Metabolic analysis showed that the total effective rate of ulcer healing was significantly higher than that of the control group (P<0.05),the total effective rate RR (95%CI) was 1.21 (1.14,1.29),the ulcer healing time (95% CI) was -3.33 (-6.05,-0.61),and there was no significant difference on adverse reaction rate between the two groups (P>0.05).The RD (95% CI) was -0.03 (-0.05,0.00).Conclusion Based on the available clinical data,oral ulcer tablets for recurrent aphthous oral ulcers is effective,but this conclusion still need more large samples,high-quality clinical randomized controlled trials to be confirmed. |
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