| 宋昕倢,叶山东,周婉,邢燕,陈燕,张一鸣.尿C肽/肌酐评估2型糖尿病患者胰岛β细胞功能的临床研究[J].中国临床保健杂志,2019,22(2):193-195. |
| 尿C肽/肌酐评估2型糖尿病患者胰岛β细胞功能的临床研究 |
| Evaluation of islet beta-cell function in type 2 diabetes mellitus by measuring urinary C-peptide/creatinine ratio |
| 投稿时间：2018-11-10 |
| DOI：10.3969/J.issn.1672-6790.2019.02.013 |
| 中文关键词: 糖尿病,2型 C肽 血糖 |
| 英文关键词: Diabetes mellitus,type 2 C-peptide Blood glucose 〖FL |
| 基金项目:国家自然科学基金(81800713)；中央引导地方科技创新专项(2017070802D147)；安徽省自然科学基金(1808085QH292) |
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| 中文摘要: |
| 目的 探讨单次尿C肽/肌酐比重(UCPCR)在评估2型糖尿病(T2DM)患者胰岛β细胞功能中的应用。 方法 通过分别测定T2DM患者和健康对照人群的尿C肽、肌酐、空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹血C肽、餐后2 h血C肽、24 h尿C肽,分析UCPCR与上述指标的相关性。 结果 T2DM患者UCPCR较对照组明显降低(P<0.05)。2型糖尿病UCPCR与空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹C肽、2 h血C肽、24 h尿C肽(r=-0.261,r=-0.372,r=-0.492,r=0.358,r=0.675,r=0.583；P<0.05)有显著相关性。 结论 尿C肽/肌酐比值可用于评估T2DM患者胰岛β细胞功能。 |
| 英文摘要: |
| Objective To explore the application of single urinary C-peptide/creatinine ratio (UCPCR) in assessing the function of islet beta cells in patients with type 2 diabetes(T2DM). Methods Urinary C-peptide,urinary creatinine,fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,fasting blood C-peptide,2-hour postprandial blood C-peptide and 24-hour urinary C-peptide were measured in patients with T2DM and healthy controls respectively.The correlation between UCPCR and fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,fasting blood C-peptide,2-hour postprandial blood C-peptide and 24-hour urinary C-peptide was analyzed. Results UCPCR in diabetic mellitus was significantly lower compared with control group (P＜0.05).UCPCR in patients with T2DM had significant correlation with fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,fasting C-Peptide and plasma 2 hours C-Peptide,and 24-hour urinary C-peptide(r=-0.261,r=-0.372,r=-0.492,r=0.358,r=0.675,r=0.583;P<0.05). Conclusion Urine C-peptide/creatinine ratio can be used to assess islet β-cell function in patients with T2DM. |
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