| 黄世明,邓清华,林俊,等.靶向治疗联合化疗对肺癌脑转移患者的治疗效果[J].中国临床保健杂志,2019,22(2):205-207. |
| 靶向治疗联合化疗对肺癌脑转移患者的治疗效果 |
| Effect of targeted therapy combined with chemotherapy on brain metastasis in patients with lung cancer |
| 投稿时间：2018-10-10 |
| DOI：10.3969/J.issn.1672-6790.2019.02.016 |
| 中文关键词: 肺肿瘤 肿瘤转移 分子靶向治疗 药物疗法 |
| 英文关键词: Lung neoplasms Neoplasm metastasis Molecular targeted therapy Drug therapy 〖FL |
| 基金项目:浙江省杭州市卫生科技重大项目(20120533201) |
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| 中文摘要: |
| 目的 探讨靶向治疗联合化疗对肺癌脑转移患者的治疗效果。 方法 选取肺癌脑转移患者91例。按照随机数字表划分为观察组(n=46)和对照组(n=45)。其中对照组患者给予单纯化疗,观察组患者给予靶向治疗联合化疗。比较两组患者治疗后的控制效果、不良反应发生情况以及生存率情况。 结果 观察组患者的治疗控制率为91.30%,显著高于对照组患者的治疗控制率77.78%,两组之间差异有统计学意义(P＜0.05)；治疗之后两组患者不良反应情况比较,观察组患者出现消化道反应、骨髓抑制、肝功能损伤、恶心呕吐情况明显少于对照组患者,前两项比较差异有统计学意义(P＜0.05)；观察组患者随访1年生存率为89.13%,2年生存率为67.39%,明显高于对照组患者的1年生存率77.78%和2年生存率55.56%,两组生存率比较差异有统计学意义(P＜0.05)。 结论 靶向治疗联合化疗对肺癌脑转移患者的治疗效果显著,可以很好地控制病情,延长患者生存周期,且安全性高。 |
| 英文摘要: |
| Objective To investigate the therapeutic effect of targeted therapy combined with chemotherapy for lung cancer with brain metastasis. Methods A total of 91 patients with brain metastases from lung cancer were selected and divided into the observation group (n=46) and the control group (n=45) according to the random number table.The patients in the control group were given chemotherapy,while the patients in the observation group were given targeted therapy combined with chemotherapy.The control effect,adverse reactions and survival rate after treatment were compared between the two groups. Results The control rate in the observation group was 91.30%,which was significantly higher than that in the control group (77.78%).The difference was statistically significant (P<0.05).After treatment,the adverse reactions of patients in the observation group were significantly less than those in the control group,such as digestive tract reaction,bone marrow suppression,liver function damage,nausea and vomiting.The 1-year survival rate and 2-year survival rate in the observation group were 89.13% and 67.39% respectively,which were significantly higher than those in the control group (77.78% and 55.56%,respectively).There was significant difference between the two groups (P<0.05). Conclusion The combination of targeted therapy and chemotherapy is effective in the treatment of lung cancer patients with brain metastasis,which can be used to control the disease,prolong the life cycle of patients with high safety. |
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