| 朱飞,周华,徐朝晖,等.乌司他丁对结肠癌患者微创外科治疗后血清炎性指标影响的分析[J].中国临床保健杂志,2019,22(3):346-348. |
| 乌司他丁对结肠癌患者微创外科治疗后血清炎性指标影响的分析 |
| Effect of ulinastatin on serum inflammatory markers in patients with colon cancer after minimally invasive surgery |
| 投稿时间：2018-12-22 |
| DOI：10.3969/J.issn.1672-6790.2019.03.014 |
| 中文关键词: 结肠肿瘤 炎症 最小侵入性外科手术 乌司他汀 |
| 英文关键词: Colonic neoplasms Inflammation Minimally invasive surgical procedures Urinastatin 〖FL |
| 基金项目:浙江省自然科学基金项目(LY13H030005) |
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| 中文摘要: |
| 目的 探索乌司他丁对结肠癌患者微创外科治疗后血清炎性指标的影响。 方法 选取248例行结肠癌微创外科择期手术患者为研究对象,按照随机数表法分为对照组和观察组各124例。对照组采用常规治疗,观察组在对照组基础上添加乌司他丁治疗。于入院当天收集患者年龄、性别、体质指数(BMI)、长期吸烟史、手术时间、TNM分期等临床资料,采集患者血液并检测血清白细胞计数(WBC)、C反应蛋白(CRP)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、降钙素原(PCT)、尿素氮(BUN)指标水平。对具有统计学意义的血清炎性指标进行效应分析,分析乌司他丁对该血清炎性指标的影响程度。 结果 手术后观察组WBC为(10.27±3.20)×109/L,CRP为(75.41±20.13)mg/L,血清炎性指标水平显著低于对照组WBC(13.95±3.47)×109/L 和CRP(114.28±31.46)mg/L,且差异具有统计学意义(P＜0.05)。固定效应系数结果显示对结肠癌患者应用乌司他丁能够在术后平均降低WBC 1.038×109/L、CRP 23.148 mg/L,且该数值与时间无交互效应。 结论 乌司他丁能够显著降低结肠癌患者微创外科治疗后血清炎性指标水平且下降幅度较大,减轻患者炎性反应并有助于患者术后康复。 |
| 英文摘要: |
| Objective To explore the effect of ulinastatin on serum inflammatory markers in patients with colon cancer after minimally invasive surgery. Methods 248 patients with colon cancer undergoing minimally invasive surgery in our hospital were selected as the research object.According to the random number table,124 patients in the control group and 124 patients in the observation group were divided into the control group and 124 patients in the control group.The control group was given routine treatment,while the observation group was given ulinastatin on the basis of the control group.The clinical data of age,sex,body mass index (BMI),long-term smoking history,operation time and TNM stage were collected on the day of admission.WBC,CRP,ALT,AST,PCT and urine were measured.Nitrogen (BUN) index level.The effects of ulinastatin on serum inflammatory markers were analyzed. Results After operation,the WBC of the observation group was (10.27±3.20)×109/L,and the CRP was (75.41±20.13)mg/L.The serum inflammation index level was significantly lower than that of the control group WBC (13.95±3.47)×109/L and CRP (114.28±31.46)mg/L,and the difference was statistically significant (P<0.05).Fixed effect coefficients showed that Ulinastatin could reduce WBC 1.038×109/L and CRP 23.148 mg/L on average after operation in patients with colon cancer,and the value had no interaction with time. Conclusion Ulinastatin can significantly reduce the level of serum inflammatory markers in patients with colon cancer after minimally invasive surgical treatment,and decrease the inflammatory response of patients and help patients recover after surgery. |
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