| 刘君君,刘佳,王培,等.老年肺癌住院患者衰弱综合征的临床特点和危险因素分析[J].中国临床保健杂志,2019,22(5):667-670. |
| 老年肺癌住院患者衰弱综合征的临床特点和危险因素分析 |
| Clinical characteristics and risk factors in elderly patients with lung cancer and frail syndrome |
| 投稿时间：2019-02-21 |
| DOI：10.3969/J.issn.1672-6790.2019.05.025 |
| 中文关键词: 肺肿瘤 衰弱 危险因素 老年人 |
| 英文关键词: Lung neoplasms Frailty Risk factors Aged 〖FL |
| 基金项目:北京医院院内课题(BJ-2012-114) |
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| 中文摘要: |
| 目的 分析老年肺癌合并衰弱综合征(FS)患者的临床特点,探讨FS患者的短期预后和危险因素。方法 本研究为回顾性队列研究。选择住院的老年(≥60岁)肺癌患者324例,根据是否合并FS分为FS组(91例)和非FS组(233例),比较两组基线和住院期间的临床资料,用多因素logistic回归分析影响FS的危险因素。结果 324例老年肺癌患者中,男性172例(53.1%),女性152例(46.9%);年龄范围60～90岁,年龄(76.4±5.7)岁。较非FS组,FS组患者的年龄较大、体质指数低、红细胞、血红蛋白、白蛋白和总蛋白水平低、易合并共病、多重用药、且营养差、日常活动能力低(P均＜0.05)。住院期间,4例FS组患者和5例非FS组患者因严重呼吸衰竭死亡,两组的病死率相似(P＞0.05),但FS组患者的住院时间明显长于对照组[(9.3±4.7) d比(7.7±5.1)d,P＜0.05]。多因素logistic 回归分析显示,年龄大、低清蛋白和营养状况差(MNA-SF较低)是FS的危险因素。结论 老年肺癌并发FS患者年龄大、体质指数低、营养差、日常活动能力低,多有共病和多重用药。高龄、低蛋白血症和营养状况差是FS的危险因素。 |
| 英文摘要: |
| Objective To evaluate the clinical characteristics and risk factors in elderly patients with lung cancer and frailty syndrome (FS).Methods We analyzed data from 324 elderly patients (≥60 years) with lung cancer.Ninety-one elderly patients who had FS were in FS group and 233 elderly patients without FS in the non-FS group.Results 324 elderly patients with a mean age of(76.4±5.7)years were enrolled.There was significant difference in the age,body mass index,comorbidity,polypharmacy,red blood cell counts,hemoglobin,albumin MNA-SF and ADL between the two groups (P＜0.05).During hospitalization,9 patient died of severe respiratory failure (4.4% vs2.1%,χ2=0.188,P=0.665).FS group was associated with markedly higher risk of mortality and longer days stayed in-hospital[(9.3±4.7) d vs(7.7±5.1) d,t=2.593,P=0.009].Cox regression analysis showed that advanced age,low albumin level and MNA-SF≤7 were risk factors for FS (all P＜0.05).Conclusions Advanced age,low serum albumin level and MNA-SF≤7 are risk factors for FS. |
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