| 刘悦晴,黄淑顺.血清脑钠肽水平与老年慢性心力衰竭患者心功能的相关性[J].中国临床保健杂志,2019,22(6):805-808. |
| 血清脑钠肽水平与老年慢性心力衰竭患者心功能的相关性 |
| Relationship between the levels of serum brain natriuretic peptide and cardiac function in elderly patients with chronic heart failure |
| 投稿时间：2019-08-11 |
| DOI：10.3969/J.issn.1672-6790.2019.06.022 |
| 中文关键词: 心力衰竭 利钠肽,脑 超声心动描记术,多普勒 老年人 |
| 英文关键词: Heart failure Natriuretic peptide,brain Echocardiography,doppler Aged 〖FL |
| 基金项目:中央引导地方科技发展专项(2017070802D145) |
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| 中文摘要: |
| 目的 探讨血清脑钠肽(BNP)和超声心动图在评估慢性心力衰竭(CHF)患者心功能中的临床价值。方法 选择120例CHF患者为观察组,同期体检的健康人群120例作为对照组,比较不同心功能分级比较超声心电图参数及BNP水平、左心射血分数(LVEF)和左心室舒张末期内径(LVEDD)。并按照心功能分级 和BNP是否正常进行分组,分析血清BNP和超声心动图与心功能分级相关性,评价血清BNP和超声心动图在评估CHF心功能分级中的价值。结果 观察组的血清BNP、LVEDD水平均高于对照组,LVEF低于对照组,差异有统计学意义(P<0.05)。按照心力衰竭级别分组,各组间的BNP水平不同,且任意两组间的BNP有统计学差异,随着心力衰竭级别的增加,BNP逐渐增加(P<0.05)；随着心力衰竭级别的增加,LVEF逐渐降低(P<0.05)；各组间的LVEDD不同,且心力衰竭Ⅲ级与Ⅰ级、Ⅳ级与Ⅰ级、Ⅳ级与Ⅱ级间差异有统计学意义(P<0.05)；随着心力衰竭级别的增加,BNP水平逐渐增加(P<0.05)但LVEF水平逐渐降低(P<0.05)；各组间的LVEDD不同,且心力衰竭Ⅲ级与Ⅰ级、Ⅳ级与Ⅰ级、Ⅳ级与Ⅱ级间差异有统计学意义(P<0.05)。血清BNP与LVEF呈负相关,但与LVEDD呈正相关(P<0.05)；BNP升高组患者的年平均住院次数、住院时间均高于对照组,差异有统计学意义(P<0.05)。结论 血清BNP和LVEF、LVEDD参数一起用于CHF患者心功能评估,可提高评估准确性,为病情评估、临床治疗提供理论指导依据。 |
| 英文摘要: |
| Objective To explore the clinical value of serum brain natriuretic peptide(BNP) and echocardiography in evaluating cardiac function in patients with chronic heart failure (CHF).Methods A total of 120 patients with CHF were selected as the observation group and 120 healthy people as the control group.The ECG parameters,the levels of BNP,left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDD) were compared among different cardiac function grades.The correlation between serum the levels of BNP and echocardio graphic parameters and cardiac function classification was analyzed,and the value of BNP and echocardiogram in evaluating cardiac function classification of CHF was evaluated.Results The levels of serum BNP and LVEDD in the observation group were higher than those in the control group,and the LVEF were lower than those in the control group (P<0.05).According to the heart failure grade,the levels of BNP were different among groups,and there were statistical differences between any two groups.With the increase of heart failure grade,the levels of BNP gradually increased (P<0.05).With the increase of heart failure grade,LVEF gradually decreased (P<0.05).LVEDD was different among groups,and there were statistical differences between heart failure grade Ⅲ and Ⅰ,Ⅲ and Ⅰ,Ⅳ and Ⅱ (P<0.05).With the increase of failure grade,the levels of BNP increased gradually (P<0.05),but LVEF decreased gradually (P<0.05).LVEDD was different among groups,and there were statistical differences between heart failure grade Ⅲ and Ⅰ,Ⅳ and Ⅰ,Ⅳ and Ⅱ (P<0.05).Serum BNP was negatively correlated with LVEF,but positively correlated with LVEDD (P<0.05).The average number of hospitalizations and hospitalization time of patients with elevated BNP were higher than those in the control group with statistical significance (P<0.05).Conclusion The levels of serum BNP,LVEF and LVEDD can be used to evaluate cardiac function in patients with CHF,which can improve the accuracy of assessment,provide theoretical basis for disease assessment and clinical treatment. |
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