| 彭旭东,刘雯雯,刘梅林,等.心型脂肪酸结合蛋白对老年人全因死亡的预测价值[J].中国临床保健杂志,2020,23(1):68-73. |
| 心型脂肪酸结合蛋白对老年人全因死亡的预测价值 |
| The predictive role of heart fatty acid binding protein in all-cause mortality in elderly people |
| 投稿时间：2019-12-17 |
| DOI：10.3969/J.issn.1672-6790.2020.01.016 |
| 中文关键词: 脂肪酸结合蛋白质3 预测 死亡原因 老年人 |
| 英文关键词: Fatty acid binding protein 3 Forecasting Cause of death Aged |
| 基金项目:中央军委后勤保障部保健专项课题(12BJZ27) |
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| 中文摘要: |
| 目的 探索心型脂肪酸结合蛋白(H-FABP)在老年人群全因死亡中的预测作用。方法 纳入65岁以上不伴冠心病的老年体检人群568例,入组时均进行基线资料采集及血清H-FABP水平的测定,共随访7年,分析H-FABP与死亡及主要不良心血管事件之间的关系。结果 随访期间,全因死亡31例,无心血管死亡,发生主要不良心血管事件33例。H-FABP对于全因死亡的预测效能高于尿素氮(BUN)、估算肾小球滤过率(eGFR)和血清白蛋白水平,并且H-FABP>3.57 μg/L可能作为全因死亡的独立危险因素。生存分析结果显示越高的H-FABP水平意味着越高的死亡风险。结论 H-FABP与老年人群的全因死亡相关。 |
| 英文摘要: |
| Objective To explore the predictive role of heart fatty acid binding protein (H-FABP) in all-cause mortality (ACM) in the elderly.Methods A total of 568 elderly people over 65 years old without coronary heart disease were enrolled.Baseline data were collected and serum H-FABP levels were measured at the time of enrollment.Long-term follow-up of the population was performed (meanly 7.4 years).The relationships between H-FABP and ACM or major adverse cardiovascular events were analyzed.Results During the follow-up period,31 patients died of all causes,no cardiac death was observed,and 33 major adverse cardiovascular events occurred.H-FABP was more effective than BUN,eGFR and serum albumin in predicting ACM,and H-FABP>3.57 μg/L could be used as an independent risk factor for ACM.Survival analysis showed that higher H-FABP level predicted higher risk of death.Conclusion Serum H-FABP is associated with ACM in the elderly. |
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