| 吴小娅,黄锡通,王爱芳,等.糖尿病动脉粥样硬化中抗栓联合降血脂治疗作用[J].中国临床保健杂志,2020,23(4):518-522. |
| 糖尿病动脉粥样硬化中抗栓联合降血脂治疗作用 |
| The therapeutic effect of anticoagulation combined with hypolipidemia in diabetic atherosclerosis |
| 投稿时间：2020-05-17 |
| DOI：10.3969/J.issn.1672-6790.2020.04.020 |
| 中文关键词: 糖尿病血管病变 动脉粥样硬化 药物疗法,联合 阿司匹林 阿托伐他汀 |
| 英文关键词: Diabetic angiopathies Atherosclerosis Drug therapy,combination Aspirin Atorvastatin |
| 基金项目:浙江省医药卫生科技计划项目(2019KY794) |
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| 中文摘要: |
| 目的 探讨糖尿病动脉粥样硬化中抗栓联合降血脂的治疗作用。方法 选取2019年1月到2020年1月玉环市人民医院诊治的92例糖尿病动脉粥样硬化患者,按照随机数字表法纳入A组(n=46)与B组(n=46),分别予以抗栓治疗与抗栓联合降血脂治疗,对比两组患者的血糖水平(空腹血糖、餐后2 h血糖、糖化血红蛋白)、血脂水平(血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇)、斑块指标(颈动脉内-中膜厚度、斑块厚度、斑块评分)、糖尿病并发症(脑血管病、眼底病变、周围神经病变、糖尿病肾病)。结果 B组治疗后的空腹血糖、餐后2 h血糖、糖化血红蛋白[(7.0±1.2)mmol/L、(8.7±2.1)mmol/L、4.9%±1.4%]均低于A组[(8.6±3.3)mmol/L、(13.0±2.3)mmol/L、6.0%±2.1%),P值均<0.05；B组治疗后的总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平[(4.22±0.60)mmol/L、(1.15±0.24)mmol/L、(1.68±0.32)mmol/L、(2.25±0.43)mmol/L]均优于A组[(5.75±0.83)mmol/L、(2.68±0.32)mmol/L、(1.25±0.35)mmol/L、(3.88±0.96)mmol/L],P值均<0.05；B组治疗后的颈动脉内-中膜厚度、斑块厚度、斑块评分[(1.14±0.22)mm、(1.87±0.10)mm、(0.60±0.12)分]均小于A组[(1.51±0.30)mm、(2.11±0.15)mm、(0.85±0.44)分],P值均<0.05；B组的糖尿病并发症发生率(4.3%)低于A组(17.4%),P<0.05。结论 糖尿病动脉粥样硬化中抗栓联合降血脂的治疗作用显著,可改善血糖、血脂水平及斑块指标,且可降低糖尿病并发症发生率。 |
| 英文摘要: |
| Objective To explore the therapeutic effect of anticoagulation combined with hypolipidemia in diabetic atherosclerosis.Methods 92 diabetic atherosclerotic patients who were diagnosed and treated in our hospital from Jan 2019 to Jan 2020 were randomly enrolled into the group A (n=46) and the group B (n=46).They were treated with anticoagulant therapy and anticoagulant combined with hypolipidemic therapy respectively.The blood glucose level (fasting blood glucose,2-hour postprandial blood glucose,glycosylated hemoglobin),blood lipid level (serum total cholesterol,triglyceride) of the two groups were compared Lipid,HDL-C,LDL-C),plaque index (carotid intima-media thickness,plaque thickness,plaque score),diabetic complications (cerebrovascular disease,fundus disease,peripheral neuropathy,diabetic nephropathy).Results The levels of fasting,2 hours after meal,and glycohemoglobin[(7.0±1.2)mmol/L,(8.7±2.1)mmol/L,4.9%±1.4%] in the group B were lower than the group A [(8.6±3.3)mmol/L,(13.0±2.3)mmol/L,6.0%±2.1%),P<0.05;the total cholesterol,triglyceride,high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in the group B after treatment [(4.22±0.60)mmol/L,(1.15±0.24)mmol/L,(1.68±0.32)mmol/L,(2.25±0.43)mmol/L] were better than the group A [(5.75±0.83)mmol/L,(2.68±0.32)mmol/L,(1.25±0.35)mmol/L,(3.88±0.96)mmol/L],P<0.05;the carotid intima-media thickness,plaque thickness,plaque score [(1.14±0.22)mm,(1.87±0.10)mm,(0.60±0.12)points) in the group B were lower than those in the group A [(1.51±0.30)mm,(2.11±0.15)mm,(0.85±0.44)points],P<0.05;the incidence of diabetic complications in the group B (4.3%) was lower than that in the group A (17.4%),P<0.05.Conclusion Anticoagulation combined with blood lipid lowering has a significant therapeutic effect on diabetic atherosclerosis,which can significantly improve the blood glucose,blood lipid level and plaque index,and reduce the incidence of diabetic complications. |
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