| 张俊,王凯.伊伐布雷定对慢性心力衰竭患者心脏功能及血清重组人半乳糖凝集素3、可溶性人基质裂解素2、 N末端B型脑钠肽前体水平的影响[J].中国临床保健杂志,2021,24(1):59-62. |
| 伊伐布雷定对慢性心力衰竭患者心脏功能及血清重组人半乳糖凝集素3、可溶性人基质裂解素2、 N末端B型脑钠肽前体水平的影响 |
| Effects of Ivabradine on cardiac function and serum Galectin-3,sST2 and NT-proBNP levels in patients with chronic heart failure |
| 投稿时间：2019-09-02 |
| DOI：10.3969/J.issn.1672-6790.2021.01.016 |
| 中文关键词: 心力衰竭 心率 每搏输出量 半乳糖凝集素3 心脏功能试验 |
| 英文关键词: Heart failure Heart rate Stroke volume Galectin 3 Heart function tests |
| 基金项目:湖北省科技计划项目(2017FFC212) |
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| 中文摘要: |
| 目的 研究伊伐布雷定对慢性心力衰竭患者心脏功能及血清重组人半乳糖凝集素3(Galectin-3)、可溶性人基质裂解素2(sST2)以及N末端B型脑钠肽前体(NT-proBNP)水平的影响。方法 选择94例慢性心力衰竭患者按随机数字表法均分为两组,各47例。对照组患者给予常规治疗,观察组患者加用伊伐布雷定,连续治疗3个月。比较治疗前后心率、心室射血分数(LVEF)、左心室收缩末期及舒张末期内径(LVESD、LVEDD),检测治疗前后血清NT-proBNP、sST2、Galectin-3水平,并比较治疗总有效率与不良事件发生率。结果 (1)观察组治疗总有效率显著高于对照组(P<0.05)；(2)治疗前两组心率及心脏功能指标差异无统计学意义(P>0.05),治疗后观察组LVESD、LVEDD、心率低于对照组,LVEF高于对照组(P<0.05)；治疗前两组血清指标水平差异无统计学意义(P>0.05),治疗后观察组血清Galectin-3、NT-proBNP水平低于对照组,sST2水平显著高于对照组(P<0.05)；两组不良事件发生率差异无统计学意义(P>0.05)。结论 伊伐布雷定能显著改善慢性心力衰竭患者心率以及心脏功能,能调节纤溶系统功能,控制心肌重塑,并提高心肌细胞功能。 |
| 英文摘要: |
| Objective To study the effects of ivabradine on cardiac function and serum recombinant human galectin-3 (Galectin-3),soluble human matrix lysin 2 (sST2) and N-terminal B-brain natriuretic peptide (NT-proBNP) levels in patients with chronic heart failure.Methods Ninety-four patients with chronic heart failure were selected.They were divided into two groups using the numerical random table method,with 47 cases in each group.Patients in the control group were given routine treatment,and patients in the observation group were added ivabradine with continuous treatment for 3 months.The heart rate,ventricular ejection fraction (LVEF),left ventricular end-systolic and end-diastolic diameter (LVESD,LVEDD) were compared before and after treatment.The levels of serum Galectin-3,sST2,and NT-proBNP were measured before and after treatment,and the total effective rate of treatment and the incidence of adverse events were compared.Results (1) The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05).(2) There was no significant difference in heart rate and cardiac function between the two groups before treatment (P>0.05).After treatment,the LVESD,LVEDD,and heart rate in the observation group were lower than those in the control group,and the LVEF in the observation group was higher than that in the control group (P<0.05).There was no significant difference in serum index between the two groups before treatment (P>0.05).After treatment,the levels of serum Galectin-3 and NT-proBNP in the observation group were lower than those in the control group,and the level of sST2 was significantly higher than that in the control group (P<0.05).There was no significant difference in the incidence of adverse events between the two groups (P>0.05).Conclusion Ivabradine can improve significantly heart rate and cardiac function,regulate fibrinolytic system function,control myocardial remodeling,and improve myocardial cell function in patients with chronic heart failure. |
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