文章摘要
王丹,殷晓明,唐文娟,等.脂蛋白(a)、同型半胱氨酸、超敏C反应蛋白和颈动脉内膜中层厚度与高血压合并冠心病相关性研究[J].中国临床保健杂志,2021,24(1):63-67.
脂蛋白(a)、同型半胱氨酸、超敏C反应蛋白和颈动脉内膜中层厚度与高血压合并冠心病相关性研究
Study on the relationship between LP a ,homocysteine,high sensitive C-reactive protein,carotid intima-media thickness and hypertension combined with coronary heart disease
投稿时间：2020-06-17  
DOI：10.3969/J.issn.1672-6790.2021.01.017
中文关键词: 高血压  冠心病  动脉内膜中膜厚度  脂蛋白(A)  半胱氨酸  C反应蛋白质  危险因素
英文关键词: Hypertension  Coronary disease  Carotid intima-media thickness  Lipoprotein
基金项目:安徽省自然科学基金项目(1808085MH281)
作者单位E-mail
王丹 安徽医科大学附属安庆医院,老年病科,安庆 246000 935011553@qq.com 
殷晓明 安徽医科大学附属安庆医院,老年病科,安庆 246000 yinxm75@163.com 
唐文娟 安徽医科大学附属安庆医院, 全科,安庆 246000  
朱红娟 安徽医科大学附属安庆医院,老年病科,安庆 246000  
常双 安徽医科大学附属安庆医院,老年病科,安庆 246000  
周航 安徽医科大学附属安庆医院,老年病科,安庆 246000  
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中文摘要:
      目的 研究脂蛋白(a)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)和颈动脉内膜中层厚度(IMT)与高血压合并冠心病患者的相关性。方法 收集符合入选标准的原发性高血压病患者145例,根据是否合并冠心病分为原发性高血压病组(对照组)70例和原发性高血压合并冠心病组(观察组)75例。分析LP(a)、Hcy、hs-CRP和IMT与冠心病患者的相关性。结果 观察组的LP(a)、Hcy、hs-CRP、IMT及斑块形成的比例高于对照组,差异均有统计学意义(P<0.05)。多因素分析显示:在调整年龄、性别后,LP(a)(OR=1.02,P<0.001)、Hcy(OR=1.30,P<0.001)、hs-CRP(OR=4.73,P<0.001)与冠心病呈正相关,且纳入IMT变量后,正相关关系仍有统计学意义。在调整年龄、性别后,IMT中左主干(OR=154.97,P<0.001)、左分叉(OR=52.74,P<0.001)、右主干(OR=183.64,P<0.001)、右分叉(OR=77.31,P<0.001)均与冠心病呈正相关。结论 LP(a),Hcy,hs-CRP均可能为高血压合并冠心病的独立危险因素。
英文摘要:
      Objective To study the relationship between lipoprotein (a) ,homocysteine (Hcy),high sensitive C-reactive protein (hs-CRP),carotid intima-media thickness (IMT) and hypertension with coronary heart disease.Methods 145 patients with essential hypertension who met the inclusion criteria were divided into two groups:70 patients in the control group and 75 patients in the observation group.The correlation between LP(a),Hcy,hs-CRP and IMT and hypertension with coronary heart disease was analyzed.Results The proportion of LP(a),Hcy,hs-CRP,IMT and plaque formation in the observation group was higher than that in the control group (P<0.05).Multivariate analysis showed that after adjusting age and gender,there was a positive correlation between LP(a) (OR=1.02,P<0.001),Hcy (OR=1.30,P<0.001),hs-CRP (OR=4.73,P<0.001) and hypertension with coronary heart disease,and the positive correlation was still statistically significant when IMT variables were included.After adjusting the age and gender,the left main trunk (OR=154.97,P<0.001),the left branch (OR=52.74,P<0.001),the right main trunk (OR=183.64,P<0.001),the right branch (OR=77.31,P<0.001) of IMT were positively correlated with hypertension and coronary heart disease.Compared with the normal group,the plaque formation group was associated with hypertension and coronary heart disease.Conclusion LP(a),Hcy,hs-CRP,IMT and plaque formation may be independent risk factors of hypertension with coronary heart disease.
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