| 刘端绘,莫毅,陈泽宇,等.含ω-3多不饱和脂肪酸早期肠内营养对老年重症肺炎患者机械通气时间与炎性因子及免疫功能的影响[J].中国临床保健杂志,2021,24(1):80-84. |
| 含ω-3多不饱和脂肪酸早期肠内营养对老年重症肺炎患者机械通气时间与炎性因子及免疫功能的影响 |
| Effects of early enteral nutrition containing ω-3PUFA on mechanical ventilation time,inflammatory factors and immune function in elderly patients with severe pneumonia |
| 投稿时间：2020-08-14 |
| DOI：10.3969/J.issn.1672-6790.2021.01.022 |
| 中文关键词: 肺炎 肠道营养 脂肪酸类,ω3 老年人 |
| 英文关键词: Pneumonia Enteral Nutrition Fatty acids,omega-3 Aged |
| 基金项目:广西壮族自治区卫生健康委员会科研项目(Z20190639) |
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| 中文摘要: |
| 目的 探讨含ω-3多不饱和脂肪酸(ω-3PUFA)早期肠内营养对老年重症肺炎患者机械通气时间、炎性因子及免疫功能的影响。方法 选取2017年10月至2020年3月梧州市红十字会医院收治的100例老年重症肺炎患者为对象,按照随机数字表法分为对照组(n=50)和观察组(n=50),对照组给予早期肠内营养支持,观察组营养液中富含ω-3多不饱和脂肪酸,比较两组机械通气时间、ICU住院时间、脱机成功率、多脏器功能障碍(MODS)发生率、营养指标[血红蛋白(HGB)、白蛋白(ALB)、前清蛋白(PAB)]、炎性因子[白细胞介素6(IL-6)、白细胞介素1(IL-1)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)]、免疫功能及不良反应发生率。结果 观察组机械通气时间和ICU住院时间短于对照组(P<0.05),两组脱机成功率和MODS发生率差异无统计学意义(P>0.05)；治疗后,观察组HGB、ALB、PAB水平均高于对照组(P<0.05),观察组血清IL-6、IL-1、TNF-α及CRP水平均低于对照组(P<0.05),观察组CD3+、CD4+、CD4+/CD8+均显著高于对照组,CD8+低于对照组(P<0.05)；两组均无不良反应发生(P>0.05)。结论 ω-3PUFA早期肠内营养可缩短老年重症肺炎患者机械通气时间,减低炎性因子,提高细胞免疫功能。 |
| 英文摘要: |
| Objective To explore effects of early enteral nutrition containing ω-3 polyunsaturated fatty acids (ω-3PUFA) on mechanical ventilation time,inflammatory factors and immune function in elderly patients with severe pneumonia.Methods A total of 100 elderly patients with severe pneumonia who were admitted to the hospital from October 2017 to March 2020 were enrolled.According to random number method,they were divided into control group (n=50) and observation group (n=50).The control group was given early enteral nutrition support.In observation group,rich ω-3PUFA was added into nutrient solution.The mechanical ventilation time,hospitalization time in ICU,success rate of weaning,incidence of multiple organ dysfunction syndrome(MODS),nutrition indexes [hemoglobin (HGB),albumin (ALB),prealbumin (PAB)],inflammatory factors [interleukin-6 (IL-6),interleukin-1 (IL-1),tumor necrosis factor-α (TNF-α),C-reactive protein (CRP)],immune function and incidence of adverse reactions were compared between the two groups.Results The mechanical ventilation time and hospitalization time in ICU in observation group were shorter than those in control group (P<0.05).There was no significant difference in success rate of weaning or incidence of MODS between the two groups (P>0.05).After treatment,levels of HGB,ALB and PAB in observation group were higher than those in control group (P<0.05),levels of serum IL-6,IL-1,TNF-α and CRP were lower than those in control group (P<0.05),CD3+,CD4+ and CD4+/CD8+ were significantly higher than those in control group (P<0.05).There were no adverse reactions in either group (P>0.05).Conclusion Early enteral nutrition containing ω-3PUFA can shorten mechanical ventilation time,reduce inflammatory factors,and improve immune function in elderly patients with severe pneumonia. |
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