| 陈特,吕庆连,张玲,等.高血压患者并发冠心病相关危险因素研究[J].中国临床保健杂志,2021,24(1):97-100. |
| 高血压患者并发冠心病相关危险因素研究 |
| Risk factors of coronary heart disease in patients with hypertension |
| 投稿时间：2020-09-26 |
| DOI：10.3969/J.issn.1672-6790.2021.01.026 |
| 中文关键词: 高血压 冠心病 危险因素 |
| 英文关键词: Hypertension Coronary disease Risk factors |
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| 中文摘要: |
| 目的 探讨高血压患者并发冠心病的相关危险因素。方法 入选对象为我院2015年1月至2019年6月收治的高血压患者,均行冠状动脉造影或冠脉CTA检查,分为冠心病组和对照组。收集两组患者的一般资料,所有患者均进行血生化指标的检查,包括血糖、血脂、尿酸、肌酐及尿素氮等,并测定血同型半胱氨酸水平。通过单因素及多因素分析研究高血压患者并发冠心病的相关因素。结果 208例高血压患者入选,其中冠心病组121例。与对照组相比,冠心病组年龄更高[(66±7)岁对(59±9)岁,P<0.001],收缩压较高[(143±20)mm Hg对(136±17)mm Hg,P=0.015],血糖[(5.5±0.6)mmol/L对(5.3±0.59)mmol/L,P=0.035]、总胆固醇[(4.87±1.16)mmol/L对(4.56±0.82)mmol/L,P=0.032]、低密度脂蛋白胆固醇[(3.00±0.85)mmol/L对(2.74±0.68)mmol/L,P=0.022]、同型半胱氨酸[(17.13±15.19)μmol/L对(13.41±10.39)μmol/L,P=0.005]水平显著高于对照组。采用前进逐步法将年龄增长、血糖、收缩压、心率、总胆固醇、LDL-C、同型半胱氨酸为自变量纳入logistic回归模型进行分析,结果发现年龄增长(OR=2.312,95%CI:1.267~4.218,P=0.006)、低密度脂蛋白胆固醇(OR=2.206,95%CI:1.205~4.041,P=0.010)、同型半胱氨酸(OR=3.572,95%CI:1.755~7.271,P<0.001)与冠心病相关。结论 高血压患者的年龄增长、较高的低密度脂蛋白胆固醇和同型半胱氨酸水平为其并发冠心病的危险因素。 |
| 英文摘要: |
| Objective To study the risk factors of coronary heart disease in elderly patients with hypertension.Methods Patients with hypertension in our department were eligible for this study from January 2015 to June 2019.All were confirmed by coronary angiography or coronary CTA.We divided all the patients into the coronary heart disease group and the control group according to whether coronary heart disease was diagnosed.Risk factors significantly associated with coronary heart disease using univariable analysis were entered into multivariable analysis to establish those independently associated with coronary heart disease.Results A total of 208 patients were enrolled in this study,and 121 patients had coronary heart disease.Patients with coronary heart disease were older [(66±7) years vs.(59±9) years,P<0.001] and had higher systolic blood pressure [(143±20) mm Hg vs.(136±17) mm Hg,P=0.015],blood glucose [(5.5±0.6) mmol/L vs.(5.3±0.59) mmol/L,P=0.035],total cholesterol [(4.87±1.16) mmol/L vs.(4.56±0.82) mmol/L,P=0.032],LDL-C [(3.00±0.85) mmol/L vs.(2.74±0.68) mmol/L,P=0.022) and homocysteine [(17.13±15.19) μmol/L vs.(13.41±10.39) μmol/L,P=0.005].Forward stepwise logistic regression analysis of the above risk factors outlines age(OR =2.312,95%CI: 1.267-4.218,P=0.006),higher LDL-C (OR=2.206,95%CI:1.205-4.041,P=0.010),higher homocysteine(OR =3.572,95%CI:1.755-7.271,P<0.001) as the independent risk factors of coronary heart disease in patients with hypertension.Conclusion Agzing,higher LDL-C level and higher homocysteine level may be the risk factors for coronary heart disease in patients with hypertension. |
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