| 孙艳秋,刘健,忻凌,等.基于数据挖掘研究中医健脾单元疗法对类风湿关节炎合并贫血患者免疫炎性指标的影响[J].中国临床保健杂志,2021,24(2):238-242. |
| 基于数据挖掘研究中医健脾单元疗法对类风湿关节炎合并贫血患者免疫炎性指标的影响 |
| Study on the effect of spleen-strengthening Unit Therapy of traditional Chinese Medicine on immune inflammatory Indexes in patients with Rheumatoid Arthritis accompanying with anemia based on data Mining |
| 投稿时间：2019-08-23 |
| DOI：10.3969/J.issn.1672-6790.2021.02.021 |
| 中文关键词: 关节炎,类风湿 贫血 从脾胃论治 中成药 数据挖掘 |
| 英文关键词: Arthritis,rheumatoid Anemia Treat Regulat Spleen Stomach Chinese Patent Drugs Data mining 〖FL |
| 基金项目:国家自然基金面上项目(81973655)；科技部国家重点研发计划中医药现代化研究重点专项资助项目(2018YFC1705204)；安徽省重点研究和开发计划对外科技合作项目(201904b11020011)；安徽省省级质量工程教学研究项目(2018jyxm1068)；安徽省名中医刘健工作室建设项目(中医药发展秘[2018]11号)；全国中医药创新骨干人才培训项目(国中医药人教函[2019]128号)；安徽省重点研究与开发计划项目(201904a07020004)；安徽现代中医内科应用基础与开发研究省级实验室项目(2016080503B041)；安徽省第12批“115”创新团队资助项目(皖人才办[2019]1号) |
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| 中文摘要: |
| 目的 运用随机行走模型等数据挖掘方法研究中医健脾单元疗法对类风湿关节炎(RA)合并贫血患者的免疫、炎性指标的影响。方法 收集整理安徽省中医院风湿科2012年6月至2018年1月类风湿关节炎合并贫血住院患者资料,依据是否使用新风胶囊内服、芙蓉膏外敷,分为研究组与对照组；通过Liquorice 软件系统构建两组中药核心处方复杂网络,运用SPSS 22.0分析研究组、对照组患者的一般情况、免疫炎性指标的变化。采用ORACLE 10g软件建立随机行走评价模型。结果 (1)共计1 251例RA贫血患者符合纳入标准,其中对照组为754例,研究组497例。(2)两组治疗前后差值相比,研究组在升高红细胞计数(RBC)、血红蛋白(Hb),降低红细胞沉降率(ESR)、超敏C反应蛋白(hs-CRP)、抗环瓜氨酸肽抗体(Anti-CCP)指标方面优于对照组,差异有统计学意义(P<0.01)。(3)经随机行走模型分析发现两组患者综合评价指标和接受的干预措施存在长程关联,研究组评价RBC、Hb、ESR、hs-CRP方面,在行走正向增长率、随机波动幂律值、综合评价指标的正向递增率、期望改善值方面,均优于对照组。结论 中医健脾单元疗法在调节RA合并贫血免疫反应、抑制炎性反应、改善贫血状态等方面具有确切疗效。 |
| 英文摘要: |
| Objective Data mining methods such as complex network technology and random walk model were used to study the effect of spleen-invigorating unit therapy of traditional Chinese medicine on immune and inflammatory indexes in patients with rheumatoid arthritis (RA) accompanying with anemia.Methods We collected the data of rheumatoid arthritis patients accompanying with anemia in rheumatology department of Anhui Hospital of Chinese medicine from June 2012 to January 2018,and divided them into experimental group and control group according to whether to use Xinfeng Capsule for internal administration and Furong Ointment for external application. We constructed the complex network of the core prescriptions of the two groups of traditional Chinese medicine through the Liquorice software system,and used SPSS 22.0 to analyze the general conditions of patients in the experimental group and the control group,the changes of immune and inflammatory indexes,and ORACLE 10g software to establish a random walking evaluation model.Results (1) A total of 1251 RA patients accompanying with anemia met the inclusion criteria,including the control group (n=754) and the experimental group (n=497).(2) Comparison of the difference between the two groups before and after treatment,the experimental group was superior to the control group in increasing RBC,Hb,and decreasing hs-CRP,ESR and anti-CCP,and the differences were statistically significant (P＜0.01).(3) Through the random walking model analysis,it was found that there was a long-term correlation between the comprehensive evaluation index and the intervention measures of the two groups. In the evaluation of RBC,Hb,ESR and hs-CRP,the experimental group was superior to the control group in walking positive growth rate,random fluctuation power law value,positive increasing rate of comprehensive evaluation index and expected improvement value.Conclusion The spleen-invigorating unit therapy of traditional Chinese medicine has a definite effect in regulating the immune responses inhibiting inflammatory reaction and improving the state of anemia of RA complicated with anemia. |
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