| 唐甜甜,董建全,于世林,等.亚临床甲状腺功能减退对老年腔隙性脑梗死患者血脂及同型半胱氨酸的影响[J].中国临床保健杂志,2021,24(3):387-390. |
| 亚临床甲状腺功能减退对老年腔隙性脑梗死患者血脂及同型半胱氨酸的影响 |
| The effects of subclinical hypothyroidism on blood lipid and homocysteine in elderly patients with lacunar infarction and its correlation |
| 投稿时间：2020-09-06 |
| DOI：10.3969/J.issn.1672-6790.2021.03.023 |
| 中文关键词: 中风,腔隙性 甲状腺功能减退症 血脂异常 半胱氨酸 危险因素 老年人 |
| 英文关键词: Stroke,lacunar Hypothyroidism Dyslipidemias Cysteine Risk factors Aged 〖FL |
| 基金项目:北京市医院管理局临床医学发展专项基金资助项目(“扬帆计划”,ZYLX201833) |
| 作者 | 单位 | E-mail | | 唐甜甜 | 北京老年医院,内分泌科,北京100095 | yhgeng1312@sina.com | | 董建全 | 北京老年医院,内分泌科,北京100095 | yhgeng1312@sina.com | | 于世林 | 北京老年医院,内分泌科,北京100095 | yhgeng1312@sina.com | | 王敏 | 北京老年医院,内分泌科,北京100095 | yhgeng1312@sina.com | | 马娜敏 | 北京老年医院,内分泌科,北京100095 | yhgeng1312@sina.com | | 彭诗洁 | 北京老年医院,内分泌科,北京100095 | yhgeng1312@sina.com | | 张翼 | 北京老年医院,教育处,北京100095 | yhgeng1312@sina.com | | 耿亚辉 | 北京老年医院,内分泌科,北京100095 | yhgeng1312@sina.com |
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| 中文摘要: |
| 目的 探讨亚临床甲状腺功能减退(简称亚临床甲减)对老年腔隙性脑梗死患者血脂代谢及同型半胱氨酸水平的影响及其相关性。方法 回顾性研究亚临床甲减合并腔隙性脑梗死患者(80例,观察组)和甲状腺功能正常的腔隙性脑梗死患者(80例,对照组)的临床资料,比较总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、高密度胆固醇(HDL-C)和血清同型半胱氨酸水平(Hcy)。采用多元logistic回归分析探讨亚临床甲减与老年腔隙性脑梗死患者并发高同型半胱氨酸血症的相关性。结果 观察组TG和LDL-C均高于对照组,HDL-C明显低于对照组,差异均有统计学意义(P＜0.05)。与对照组比较,观察组不仅高同型半胱氨酸血症的比例更高且整体水平也更高(P＜0.05),多元logistic回归分析表明合并亚临床甲减是腔隙性脑梗死患者并发高同型半胱氨酸血症的危险因素[OR=2.301,95％CI:1.239~6.076,P=0.017]。结论 亚临床甲减可从不同方面影响老年腔隙性脑梗死患者的血脂和同型半胱氨酸水平,合并亚临床甲减是腔隙性脑梗死患者并发高同型半胱氨酸血症的危险因素。 |
| 英文摘要: |
| Objective To explore the effects of subclinical hypothyroidism on blood lipid metabolism and homocysteine levels and their correlations of elderly patients with lacunar infarction.Methods The clinical data of lacunar infarction patients were retrospectively analyzed.80 patients with subclinical hypothyroidism (SCH) were included in the observation group,and another 80 patients with normal thyroid function were included in the control group.The total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),triacylglycerol (TG),high-density cholesterol (HDL-C) and serum homocysteine levels (Hcy) of the two groups were compared.Multivariate logistic regression analysis was used to explore the correlation between SCH and geriatric patients with lacunar infarction complicated by hyper homocysteinemia.Results The TG and LDL-C of observation group were higher than those of the control group.The HDL-C was significantly lower than that of the control group.The differences were statistically significant (P＜0.05).Compared with the control group,the observation group not only had a higher proportion of hyperhomocysteinemia,but also a higher overall level (P＜0.05).Multiple logistic regression analysis showed that subclinical hypothyroidism was the risk factors of hyperhomocysteinemia complicated by patients with lacunar infarction (OR=2.301,95%CI:1.239-6.076,P=0.017).Conclusion Subclinical hypothyroidism has a definite effect on the lipid metabolism and levels of homocysteine in elderly patients with lacunar infarction,and SCH is a risk factor for lacunar infarction patients complicated with hyperhomocysteinemia. |
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