| 徐梓铭,侯晶晶,张青,等.非外伤性玻璃体出血病因分析及不同抗血管内皮生长因子药物治疗的效果[J].中国临床保健杂志,2021,24(3):391-393. |
| 非外伤性玻璃体出血病因分析及不同抗血管内皮生长因子药物治疗的效果 |
| Etiological analysis of non-traumatic vitreous hemorrhage and study of different Anti-VEGF drugs |
| 投稿时间：2021-01-21 |
| DOI：10.3969/J.issn.1672-6790.2021.03.024 |
| 中文关键词: 玻璃体出血 危险因素 药物疗法 血管内皮生长因子类 |
| 英文关键词: Vitreous Hemorrhage Risk factors Drug therapy Vascular endothelial growth factors 〖FL |
| 基金项目:安徽省高等学校省级质量工程项目(2019jyxm1009);安徽医科大学校科研基金项目(2018xkj042) |
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| 中文摘要: |
| 目的 探讨非外伤性玻璃体出血的相关病因及不同抗血管内皮生长因子药物对玻璃体出血治疗的效果。方法 选取2018年6月至2020年6月安徽医科大学第二附属医院眼科住院非外伤玻璃体出血病历288例362眼,分析病因。对比研究其中不同抗血管内皮生长因子(VEGF)药物治疗玻璃体出血的病例79例121眼.按照给予VEGF药物的不同,分为康柏西普组59眼和雷珠单抗组62眼,比较分析两组手术前后视力变化等。结果 糖尿病视网膜病变178眼(49.17%),发生率最高,其次是视网膜分支静脉阻塞52眼(14.36%),Eales病33眼(9.11%),视网膜中央静脉阻塞26眼(7.18%)等。注射药物前后,康柏西普组和雷珠单抗组的组间和组内的视力差异无统计学意义(P＞0.05)；两组并发症发生率差异无统计学意义(P＞0.05)。结论 非外伤玻璃体出血病因前3位的分别是:糖尿病视网膜病变、视网膜分支静脉阻塞、Eales病；男性比女性非外伤玻璃体出血发病提前；康柏西普和雷珠单抗治疗的效果相当。 |
| 英文摘要: |
| Objective To investigate the etiology of vitreous hemorrhage in non traumatic eyes and the effect of different anti vascular endothelial growth factor drugs on vitreous hemorrhage.Methods 288 cases (362 eyes) of non traumatic vitreous hemorrhage in our hospital from June 2018 to June 2020 were selected to analyze the etiology;79 cases (121 eyes) of vitreous hemorrhage treated with different VEGF drugs were compared.According to the different VEGF drugs,they were divided into conbercept group (59 eyes) and ranibizumab group (62 eyes).The changes of visual acuity before and after operation were compared between the two groups.Results The incidence rate of diabetic retinopathy in 178 eyes (49.17%) was the highest,followed by 52 eyes (14.36%) of branch retinal vein occlusion,33 eyes (9.11%) of Eales's disease,26 eyes (7.18%) of central retinal vein occlusion.Before and after injection,there was no significant difference in the visual acuity between the two groups (P＞0.05);there was no significant difference in the incidence of complications between the two groups (P＞0.05).Conclusions The top three causes of non traumatic vitreous hemorrhage are diabetic retinopathy,branch retinal vein occlusion and Eales disease;men have an earlier onset of non-traumatic vitreous hemorrhage than women;the effects of conbercept and ranibizumab are equivalent. |
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