| 周爱国,郑梦利,张书新,等.肺癌患者血清癌胚抗原和神经元特异性烯醇化酶联合检测的临床意义[J].中国临床保健杂志,2021,24(5):618-622. |
| 肺癌患者血清癌胚抗原和神经元特异性烯醇化酶联合检测的临床意义 |
| Clinical significance of combined detection of serum CEA and NSE tumor markers in patients with lung cancer |
| 投稿时间：2021-05-17 |
| DOI：10.3969/J.issn.1672-6790.2021.05.008 |
| 中文关键词: 癌,非小细胞肺 生物标记,肿瘤 癌胚抗原 磷酸丙酮酸水合酶 危险因素 |
| 英文关键词: Carcinoma,non-small-cell lung Biomarkers,tumor Carcinoembryonic antigen Phosphopyruvate hydratase Risk factors |
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| 中文摘要: |
| 目的 探讨肺癌患者血清癌胚抗原(CEA)和神经元特异性烯醇化酶(NSE)联合检测的临床意义。方法 选择2017年8月至2020年12月在解放军总医院第八医学中心诊治的非小细胞肺癌患者78例作为肺癌组,同期选择在同一医院体检的健康人群78例作为健康组,检测两组血清CEA、NSE表达水平,调查患者的病理特征并进行相关性分析,判定诊断价值。结果 肺癌组的血清CEA和NSE含量都高于健康组(P＜0.05)。肺癌组的CEA、NSE与联合检测阳性率为47.4%、48.7%、55.1%,高于健康组的2.6%、3.8%、5.1%(P＜0.05)。在肺癌组中,不同组织学分化程度、临床分期、淋巴结转移患者的血清CEA和NSE含量差异有统计学意义(P＜0.05)。Pearson相关分析显示CEA、NSE与淋巴结转移存在相关性(P＜0.05)。二分类变量logistic回归分析显示CA21-1、鳞状细胞癌抗原(SCC)、胃泌素释放肽前体(ProGRP)为影响肺癌患者淋巴结转移的主要影响因素(P＜0.05)。受试者操作特征(ROC)曲线分析显示CEA、NSE与联合检测诊断非小细胞肺癌的曲线下面积分别0.765,0.675,0.814,诊断敏感性分别为47.4%、48.7%和55.1%,特异性分别为97.4%、96.2%、94.9%。结论 肺癌患者血清CEA和NSE呈现高表达状况,与患者的病理特征存在相关性,CEA和NSE联合检测能提高对肺癌的诊断敏感性,且不会降低诊断特异性。 |
| 英文摘要: |
| Objective To explore the clinical significance of combined detection of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) tumor markers in serum of patients with lung cancer.Methods From August 2017 to December 2020,78 cases of patients with non-small cell lung cancer diagnosed and treated in this hospital were selected as the lung cancer group,and 78 cases of healthy people who received physical examination in the hospital during the same period were selected as the healthy group,and the serum CEA and NSE expression levelof the two groups were tested,investigated the patient′s pathological characteristics and given correlation analysis,and were to determine the diagnostic values.Results The levels of serum CEA and NSE in the lung cancer group were higher than those in the healthy group (P＜0.05).The positive rates of CEA,NSE and combined tests in the lung cancer group were 47.4%,48.7%,and 55.1%,which were higher than the healthy group′s 2.6%,3.8%,and 5.1% (P＜0.05).In the lung cancer group,the serum CEA and NSE levels of patients with different histological differentiation,clinical stages,and lymph node metastasis compared were significantly different (P＜0.05).Pearson correlation analysis showed that CEA,NSE were correlated with lymph node metastasis (P＜0.05).Logistic regression analysis of binary variables showed that CA21-1,SCC,and ProGRP were the main factors affected lymph node metastasis in patients with lung cancer (P＜0.05).Receiver operating characteristic (ROC) curve analysis showed that the areas under the curve for CEA,NSE and combined detection for non-small cell lung cancer were 0.765,0.675,and 0.814,respectively,and the diagnostic sensitivity were 47.4%,48.7%,and 55.1%,respectively.The specificities were 97.4%,96.2%,and 94.9%,respectively.Conclusions The serum tumor markers-CEA and NSE in patients with lung cancer are highly expressed,which are correlated with the pathological characteristics of the patients.The combined detection of CEA and NSE can improve the diagnostic sensitivity of lung cancer without reducing the diagnostic specificity. |
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